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dc.contributor.authorDempsey, Clare E
dc.contributor.authorDive, Caroline
dc.contributor.authorFletcher, Daniel J
dc.contributor.authorBarnes, Frances A
dc.contributor.authorLobo, Alan
dc.contributor.authorBingle, Colin D
dc.contributor.authorWhyte, Moira K B
dc.contributor.authorRenshaw, Stephen A
dc.date.accessioned2009-07-24T15:18:59Z
dc.date.available2009-07-24T15:18:59Z
dc.date.issued2005-07-04
dc.identifier.citationExpression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. 2005, 579 (17):3646-50 FEBS Lett.en
dc.identifier.issn0014-5793
dc.identifier.pmid15961081
dc.identifier.doi10.1016/j.febslet.2005.05.050
dc.identifier.urihttp://hdl.handle.net/10541/75634
dc.description.abstractReduced expression of pro-apoptotic Bcl-2 family proteins has been described in many gastrointestinal cancers, and may play a role in tumourigenesis. The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract. In colon, four alternatively spliced isoforms were identified; of which two are pro-apoptotic when overexpressed. In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8/10 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. These data suggest that pro-apoptotic isoforms of Bfk may help to protect against the development of human gastrointestinal malignancy.
dc.language.isoenen
dc.subjectGastrointestinal Canceren
dc.subject.meshAlternative Splicing
dc.subject.meshAmino Acid Sequence
dc.subject.meshApoptosis
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshCytoplasm
dc.subject.meshDown-Regulation
dc.subject.meshGastrointestinal Neoplasms
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshHumans
dc.subject.meshMolecular Sequence Data
dc.subject.meshProtein Isoforms
dc.subject.meshProto-Oncogene Proteins c-bcl-2
dc.subject.meshRNA, Messenger
dc.titleExpression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.en
dc.typeArticleen
dc.contributor.departmentAcademic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom.en
dc.identifier.journalFEBS Lettersen
html.description.abstractReduced expression of pro-apoptotic Bcl-2 family proteins has been described in many gastrointestinal cancers, and may play a role in tumourigenesis. The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract. In colon, four alternatively spliced isoforms were identified; of which two are pro-apoptotic when overexpressed. In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8/10 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. These data suggest that pro-apoptotic isoforms of Bfk may help to protect against the development of human gastrointestinal malignancy.


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