Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract.
AuthorsDempsey, Clare E
Fletcher, Daniel J
Barnes, Frances A
Bingle, Colin D
Whyte, Moira K B
Renshaw, Stephen A
AffiliationAcademic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom.
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AbstractReduced expression of pro-apoptotic Bcl-2 family proteins has been described in many gastrointestinal cancers, and may play a role in tumourigenesis. The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract. In colon, four alternatively spliced isoforms were identified; of which two are pro-apoptotic when overexpressed. In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8/10 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. These data suggest that pro-apoptotic isoforms of Bfk may help to protect against the development of human gastrointestinal malignancy.
CitationExpression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. 2005, 579 (17):3646-50 FEBS Lett.
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