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    Estimation of haemopoietic progenitor cells in peripheral blood by the Advia 120 and BD vantage flow cytometer: a direct comparison for the prediction of adequate collections.

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    Authors
    Greenfield, Hayley M
    Sweeney, D A
    Newton, R K
    Leather, Angela
    Murray, John
    Angelica, R
    Swindell, Ric
    Chang, James
    Affiliation
    Department of Haematology, Christie Hospital, Manchester, UK. hayleygreenfield@tiscali.co.uk
    Issue Date
    2005-10
    
    Metadata
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    Abstract
    Peripheral blood stem cells are increasingly used to ensure rapid haematological engraftment after myeloablative chemotherapy. After mobilization, progenitor cells in the blood can be enumerated to predict an adequate collection by leukapheresis. The Advia 120 automated counter has an immature cell channel measuring a parameter known as large undifferentiated cells (LUC's), which were quantified to assess their value in refining the timing of apheresis. Data were available from 102 apheresis sessions. Positive correlation was found for peripheral blood CD34+ cells and apheresis counts (r = 0.82, P < 0.0005) but not for total WCC (r = -0.15, P = 0.13) or LUC count (r = 0.12, P = 0.23). Our results indicate that the LUC population in peripheral blood has no relevance to the subsequent CD34 content of the apheresis product and CD34 cell enumeration by flow cytometry is advocated.
    Citation
    Estimation of haemopoietic progenitor cells in peripheral blood by the Advia 120 and BD vantage flow cytometer: a direct comparison for the prediction of adequate collections. 2005, 27 (5):287-91 Clin Lab Haematol
    Journal
    Clinical and Laboratory Haematology
    URI
    http://hdl.handle.net/10541/74919
    DOI
    10.1111/j.1365-2257.2005.00712.x
    PubMed ID
    16178906
    Type
    Article
    Language
    en
    ISSN
    0141-9854
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2257.2005.00712.x
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