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    Thoracic radiation therapy for limited-stage small-cell lung cancer: unanswered questions.

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    Authors
    Faivre-Finn, Corinne
    Lorigan, Paul C
    West, Catharine M L
    Thatcher, Nick
    Affiliation
    Clinical Oncology Department, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. corinne.finn@christie-tr.nwest.nhs.uk
    Issue Date
    2005-07
    
    Metadata
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    Abstract
    The role of thoracic radiation therapy (RT; TRT) is now established in the management of limited-stage small-cell lung cancer (SCLC). There is increasing evidence in the literature in favor of early concurrent chemoradiation therapy, and a gold standard of care for patients with a good performance status is twice-daily TRT (45 Gy in 3 weeks) with concurrent cisplatin/etoposide. Five-year survival rates > 20% can be expected with this combined-modality approach. Although current clinical trials are exploring the efficacy of new chemotherapeutic strategies for the disease, essential questions related to the optimization of TRT remain unanswered. In particular, the optimal RT dose, fractionation, and treatment volume have not been defined. This review highlights the need for well-designed multinational trials aimed at the optimization and standardization of RT for limited-stage SCLC. These trials should integrate translational research studies to investigate the molecular basis of RT resistance and to develop biomarker profiles of prognosis.
    Citation
    Thoracic radiation therapy for limited-stage small-cell lung cancer: unanswered questions. 2005, 7 (1):23-9 Clin Lung Cancer
    Journal
    Clinical Lung Cancer
    URI
    http://hdl.handle.net/10541/74898
    PubMed ID
    16098241
    Type
    Article
    Language
    en
    ISSN
    1525-7304
    Collections
    All Christie Publications

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