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    Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians.

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    Authors
    Saad, Abir A
    O'Connor, Peter J
    Mostafa, Mostafa H
    Metwalli, Nabila E
    Cooper, Donald P
    Povey, Andrew C
    Margison, Geoffrey P
    Affiliation
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.
    Issue Date
    2005
    
    Metadata
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    Abstract
    Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27-5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85-3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83-6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47-3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.
    Citation
    Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians., 20 (1):69-72 Int. J. Biol. Markers
    Journal
    The International Journal of Biological Markers
    URI
    http://hdl.handle.net/10541/74821
    PubMed ID
    15832776
    Type
    Article
    Language
    en
    ISSN
    0393-6155
    Collections
    All Paterson Institute for Cancer Research

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