Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians.
Authors
Saad, Abir AO'Connor, Peter J
Mostafa, Mostafa H
Metwalli, Nabila E
Cooper, Donald P
Povey, Andrew C
Margison, Geoffrey P
Affiliation
Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.Issue Date
2005
Metadata
Show full item recordAbstract
Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27-5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85-3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83-6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47-3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.Citation
Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians., 20 (1):69-72 Int. J. Biol. MarkersJournal
The International Journal of Biological MarkersPubMed ID
15832776Type
ArticleLanguage
enISSN
0393-6155Collections
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