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    Anti-CD 40 monoclonal antibody.

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    Authors
    Geldart, Tom
    Illidge, Timothy M
    Affiliation
    Cancer Research UK Oncology Unit, Cancer Sciences Division, School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK.
    Issue Date
    2005-08
    
    Metadata
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    Abstract
    Normal, bi-directional interactions between CD 40 and its natural ligand CD 154 (CD 40 ligand) are central to the generation of both T cell-dependent, humoral immune responses and cytotoxic T-cell responses. CD 40 is expressed on a broad range of hematological and epithelial malignancies. The development of monoclonal antibodies directed against CD 40 allows effective targeting of malignant cells through multiple mechanisms that include the recruitment of immune effector mechanisms such as complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity, direct anti-proliferative effects on neoplastic cells and, importantly, by the activation of tumor-targeted cellular cytotoxicity. This review provides the background to the early clinical trial data that are now beginning to emerge for this potentially exciting new treatment approach.
    Citation
    Anti-CD 40 monoclonal antibody. 2005, 46 (8):1105-13 Leuk. Lymphoma
    Journal
    Leukemia & Lymphoma
    URI
    http://hdl.handle.net/10541/74818
    DOI
    10.1080/10428190500085255
    PubMed ID
    16085550
    Type
    Article
    Language
    en
    ISSN
    1042-8194
    ae974a485f413a2113503eed53cd6c53
    10.1080/10428190500085255
    Scopus Count
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    All Paterson Institute for Cancer Research

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