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    Investigating FTIR based histopathology for the diagnosis of prostate cancer.

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    Authors
    Baker, Matthew J
    Gazi, Ehsan
    Brown, Michael D
    Shanks, Jonathan H
    Clarke, Noel W
    Gardner, Peter
    Affiliation
    Manchester Interdisciplinary Biocentre, Centre for Instrumentation and Analytical Science, School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester, UK.
    Issue Date
    2009-02
    
    Metadata
    Show full item record
    Abstract
    Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, is subjective and limited by variation between different pathologists. The diagnostic problems associated with the correct grading and staging of prostate cancer (CaP) has led to an interest in the development of spectroscopic based diagnostic techniques. FTIR microspectroscopy used in combination with a Principal Component Discriminant Function Analysis (PC-DFA) was applied to investigate FTIR based histopathology for the diagnosis of CaP. In this paper we report the results of a large patient study in which FTIR has been proven to grade CaP tissue specimens to a high degree of sensitivity and specificity.
    Citation
    Investigating FTIR based histopathology for the diagnosis of prostate cancer. 2009, 2 (1-2):104-13 J Biophotonics
    Journal
    Journal of Biophotonics
    URI
    http://hdl.handle.net/10541/74013
    DOI
    10.1002/jbio.200810062
    PubMed ID
    19343689
    Type
    Article
    Language
    en
    ISSN
    1864-0648
    ae974a485f413a2113503eed53cd6c53
    10.1002/jbio.200810062
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Pathology
    Urological Oncology
    School of Cancer and Imaging Sciences

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