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    Microfluidic technology for PET radiochemistry.

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    Authors
    Gillies, James M
    Prenant, C
    Chimon, G N
    Smethurst, G J
    Dekker, Bronwen A
    Zweit, Jamal
    Affiliation
    Cancer Research-UK/University of Manchester Radiochemical Targeting and Imaging Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. jgillies@picr.man.ac.uk
    Issue Date
    2006-03
    
    Metadata
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    Abstract
    This paper describes the first application of a microfabricated reaction system to positron emission tomography (PET) radiochemistry. We have applied microfluidic technology to synthesise PET radiopharmaceuticals using (18)F and (124)I as labels for fluorodeoxyglucose (FDG) and Annexin-V, respectively. These reactions involved established methods of nucleophilic substitution on a mannose triflate precursor and direct iodination of the protein using iodogen as an oxidant. This has demonstrated a proof of principle of using microfluidic technology to radiochemical reactions involving low and high molecular weight compounds. Using microfluidic reactions, [(18)F]FDG was synthesised with a 50% incorporation of the available F-18 radioactivity in a very short time of 4s. The radiolabelling efficiency of (124)I Annexin-V was 40% after 1 min reaction time. Chromatographic analysis showed that such reaction yields are comparable to conventional methods, but in a much shorter time. The yields can be further improved with more optimisation of the microfluidic device itself and its fluid mixing profiles. This demonstrates the potential for this technology to have an impact on rapid and simpler radiopharmaceutical synthesis using short and medium half-life radionuclides.
    Citation
    Microfluidic technology for PET radiochemistry. 2006, 64 (3):333-6 Appl Radiat Isot
    Journal
    Applied Radiation and Isotopes
    URI
    http://hdl.handle.net/10541/73115
    DOI
    10.1016/j.apradiso.2005.08.009
    PubMed ID
    16290947
    Type
    Article
    Language
    en
    ISSN
    0969-8043
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.apradiso.2005.08.009
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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