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    No association between N7-methyldeoxyguanosine and 8-oxodeoxyguanosine levels in human lymphocyte DNA.

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    Authors
    Harrison, Kathryn L
    Crosbie, Philip A J
    Agius, Raymond M
    Barber, Philip V
    Carus, Mark
    Margison, Geoffrey P
    Povey, Andrew C
    Affiliation
    Centre for Occupational and Environmental Health, Division of Epidemiology and Health Sciences, Medical School, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
    Issue Date
    2006-08-30
    
    Metadata
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    Abstract
    To examine associations between two different classes of DNA damage that can occur through endogenous processes or exogenous exposures such as smoking, N7-methyldeoxyguanosine (N7-MedG) and 8-oxodeoxyguanosine (8-oxodG) levels were measured in lymphocyte DNA from 22 bronchoscopy patients. 8-OxodG and N7-MedG was detected in 100% and 91% of samples, respectively with 8-oxodG levels being approx 20 times higher (mean 8.39+/-3.578-oxodG/10(6)dG versus 0.41+/-0.33 N7-MedG/10(6) dG) which provides an indication of the relative importance of the agents that induce oxidative DNA damage or alkylation damage. The sources of these genotoxic lesions remain to be established but N7-MedG and 8-oxodG levels were not correlated (r(2)<0.01) suggesting that there is no association between alkylating agent and reactive oxygen species exposure, their metabolism and/or the DNA repair processes that can remove this DNA damage.
    Citation
    No association between N7-methyldeoxyguanosine and 8-oxodeoxyguanosine levels in human lymphocyte DNA. 2006, 600 (1-2):125-30 Mutat. Res.
    Journal
    Mutation Research
    URI
    http://hdl.handle.net/10541/73114
    DOI
    10.1016/j.mrfmmm.2006.03.005
    PubMed ID
    16765387
    Type
    Article
    Language
    en
    ISSN
    0027-5107
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.mrfmmm.2006.03.005
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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