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    An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity.

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    Authors
    Ozensoy, Ozen
    Kockar, Feray
    Arslan, Oktay
    Isik, Semra
    Supuran, Claudiu T
    Lyon, Malcolm
    Affiliation
    Balikesir University Faculty of Science and Literature, Department of Chemistry, Soma Street, 10100 Balikesir, Turkey. ozensoy@balikesir.edu.tr
    Issue Date
    2006-08
    
    Metadata
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    Abstract
    OBJECTIVES: The antioxidant enzyme catalase and the CO2/HCO3- exchange enzyme carbonic anhydrase are both present in significant amounts in the cytosol of erythrocytes. The aim of the present study was to investigate whether these erythrocyte enzyme activities are altered in patients who have carcinoma. DESIGN AND METHODS: Cytosolic erythrocyte enzyme activities were measured in 108 cancer patients presenting with carcinoma at one of variable sites, prior to clinical treatment. These were compared with an age- and sex-matched control group of 31 healthy volunteers. RESULTS: Mean (+/-SD) catalase activities did not differ significantly, i.e. 0.0035 (+/-0.0015) EU/ml in carcinoma patients vs. 0.0031 (+/-0.00075) EU/ml in controls. However, mean carbonic anhydrase activities of 204 (+/-91) EU/ml in the carcinoma patients were significantly higher than the 158 (+/-35) EU/ml in controls (P value of 0.0065). CONCLUSION: Cytosolic erythrocyte carbonic anhydrase levels may warrant further investigation as a potential peripheral marker in cancer.
    Citation
    An evaluation of cytosolic erythrocyte carbonic anhydrase and catalase in carcinoma patients: an elevation of carbonic anhydrase activity. 2006, 39 (8):804-9 Clin. Biochem.
    Journal
    Clinical Biochemistry
    URI
    http://hdl.handle.net/10541/72953
    DOI
    10.1016/j.clinbiochem.2006.03.001
    PubMed ID
    16624271
    Type
    Article
    Language
    en
    ISSN
    0009-9120
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clinbiochem.2006.03.001
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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