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    Anti-angiogenic therapy in the treatment of advanced renal cell cancer.

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    Authors
    Board, Ruth E
    Thistlethwaite, Fiona C
    Hawkins, Robert E
    Affiliation
    Cancer Research UK Department Medical Oncology, Christie Hospital, Manchester M20 4BX, UK. Ruth.Board@christie-tr.nwest.nhs.uk
    Issue Date
    2007-02
    
    Metadata
    Show full item record
    Abstract
    Metastatic renal cell cancer is associated with a poor prognosis and is resistant to traditional chemotherapy agents. The majority of tumours are associated with inactivation of the von Hippel-Lindau gene and subsequent overexpression of proangiogenic factors, including vascular endothelial growth factor (VEGF). Drugs targeting these pathways have undergone clinical testing in renal cell cancer with encouraging results. This type of therapy is set to revolutionise the treatment of renal cell cancer and this review outlines recent evidence from clinical trials investigating the most promising of these agents.
    Citation
    Anti-angiogenic therapy in the treatment of advanced renal cell cancer. 2007, 33 (1):1-8 Cancer Treat. Rev.
    Journal
    Cancer Treatment Reviews
    URI
    http://hdl.handle.net/10541/72889
    DOI
    10.1016/j.ctrv.2006.08.003
    PubMed ID
    17071006
    Type
    Article
    Language
    en
    ISSN
    0305-7372
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctrv.2006.08.003
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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