Anti-angiogenic therapy in the treatment of advanced renal cell cancer.
Affiliation
Cancer Research UK Department Medical Oncology, Christie Hospital, Manchester M20 4BX, UK. Ruth.Board@christie-tr.nwest.nhs.ukIssue Date
2007-02
Metadata
Show full item recordAbstract
Metastatic renal cell cancer is associated with a poor prognosis and is resistant to traditional chemotherapy agents. The majority of tumours are associated with inactivation of the von Hippel-Lindau gene and subsequent overexpression of proangiogenic factors, including vascular endothelial growth factor (VEGF). Drugs targeting these pathways have undergone clinical testing in renal cell cancer with encouraging results. This type of therapy is set to revolutionise the treatment of renal cell cancer and this review outlines recent evidence from clinical trials investigating the most promising of these agents.Citation
Anti-angiogenic therapy in the treatment of advanced renal cell cancer. 2007, 33 (1):1-8 Cancer Treat. Rev.Journal
Cancer Treatment ReviewsDOI
10.1016/j.ctrv.2006.08.003PubMed ID
17071006Type
ArticleLanguage
enISSN
0305-7372ae974a485f413a2113503eed53cd6c53
10.1016/j.ctrv.2006.08.003
Scopus Count
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