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    X-linked inhibitor of apoptosis protein as a therapeutic target.

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    Authors
    Dean, Emma J
    Ranson, Malcolm R
    Blackhall, Fiona H
    Dive, Caroline
    Affiliation
    Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. emma.dean@christie.nhs.uk
    Issue Date
    2007-11
    
    Metadata
    Show full item record
    Abstract
    Dysregulation of apoptosis has been shown to contribute to many diseases, including cancer formation, development and resistance, as well as neurodegenerative and autoimmune disorders. One mechanism through which tumour cells are believed to acquire resistance to apoptosis is by overexpression of X-linked inhibitor of apoptosis protein (XIAP), which belongs to a family of inhibitor of apoptosis proteins. When XIAP is overexpressed, cancer cells are rendered resistant to apoptosis, both intrinsically and in response to chemotherapy and radiotherapy. Significant progress has been made in targeting XIAP therapeutically, both directly and indirectly through the modulation of other molecules involved in the apoptotic pathway. This review introduces XIAP from its molecular origins, discusses its modulation and potential as a novel drug target, and considers future therapeutic perspectives.
    Citation
    X-linked inhibitor of apoptosis protein as a therapeutic target. 2007, 11 (11):1459-71 Expert Opin. Ther. Targets
    Journal
    Expert Opinion on Therapeutic Targets
    URI
    http://hdl.handle.net/10541/72887
    DOI
    10.1517/14728222.11.11.1459
    PubMed ID
    18028010
    Type
    Article
    Language
    en
    ISSN
    1744-7631
    ae974a485f413a2113503eed53cd6c53
    10.1517/14728222.11.11.1459
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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