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    Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic.

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    Authors
    Dean, Emma J
    Ranson, Malcolm R
    Blackhall, Fiona H
    Holt, Sarah V
    Dive, Caroline
    Affiliation
    Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom. emma.dean@christie-tr.nwest.nhs.uk <emma.dean@christie-tr.nwest.nhs.uk>
    Issue Date
    2007-04
    
    Metadata
    Show full item record
    Abstract
    Lung cancer is the leading cause of cancer death worldwide. Despite the introduction of new agents and schedules, chemotherapy still obtains unsatisfactory overall response rates, rare complete remissions and responses of relatively short duration. The inhibitor of apoptosis proteins (IAPS) are a family of caspase inhibitors that selectively bind and inhibit caspases-3, -7, and -9. As caspase activation is central to apoptosis, novel therapeutic drugs that target IAPs enabling apoptosis to occur have potential as a treatment of malignancy. Several agents that target core components of the apoptotic signalling pathway are currently at an early stage of development. This review reports the progress being made in characterising the IAP family, with a focus on the available data relevant to the treatment of lung cancer.
    Citation
    Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic. 2007, 33 (2):203-12 Cancer Treat. Rev.
    Journal
    Cancer Treatment Reviews
    URI
    http://hdl.handle.net/10541/72880
    DOI
    10.1016/j.ctrv.2006.11.002
    PubMed ID
    17210228
    Type
    Article
    Language
    en
    ISSN
    0305-7372
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctrv.2006.11.002
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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