Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic.
Affiliation
Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom. emma.dean@christie-tr.nwest.nhs.uk <emma.dean@christie-tr.nwest.nhs.uk>Issue Date
2007-04
Metadata
Show full item recordAbstract
Lung cancer is the leading cause of cancer death worldwide. Despite the introduction of new agents and schedules, chemotherapy still obtains unsatisfactory overall response rates, rare complete remissions and responses of relatively short duration. The inhibitor of apoptosis proteins (IAPS) are a family of caspase inhibitors that selectively bind and inhibit caspases-3, -7, and -9. As caspase activation is central to apoptosis, novel therapeutic drugs that target IAPs enabling apoptosis to occur have potential as a treatment of malignancy. Several agents that target core components of the apoptotic signalling pathway are currently at an early stage of development. This review reports the progress being made in characterising the IAP family, with a focus on the available data relevant to the treatment of lung cancer.Citation
Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic. 2007, 33 (2):203-12 Cancer Treat. Rev.Journal
Cancer Treatment ReviewsDOI
10.1016/j.ctrv.2006.11.002PubMed ID
17210228Type
ArticleLanguage
enISSN
0305-7372ae974a485f413a2113503eed53cd6c53
10.1016/j.ctrv.2006.11.002
Scopus Count
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