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dc.contributor.authorBrown, Michael D
dc.contributor.authorHart, Claire A
dc.contributor.authorGazi, Ehsan
dc.contributor.authorBagley, Steven
dc.contributor.authorClarke, Noel W
dc.date.accessioned2009-07-07T15:50:41Z
dc.date.available2009-07-07T15:50:41Z
dc.date.issued2006-03-27
dc.identifier.citationPromotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs. 2006, 94 (6):842-53 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid16523199
dc.identifier.doi10.1038/sj.bjc.6603030
dc.identifier.urihttp://hdl.handle.net/10541/72866
dc.description.abstractEpidemiological studies have shown not only a relationship between the intake of dietary lipids and an increased risk of developing metastatic prostate cancer, but also the type of lipid intake that influences the risk of metastatic prostate cancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been shown to enhance the proliferation of malignant prostate epithelial cells and increase the risk of advanced prostate cancer. However, its role in potentiating the migration of cancer cells is unknown. Here we show that arachidonic acid at concentrations
dc.language.isoenen
dc.subjectBone Marrow Canceren
dc.subjectCancer Invasivenessen
dc.subjectProstatic Canceren
dc.subjectTumour Cellsen
dc.subject.meshArachidonic Acid
dc.subject.meshBone Marrow Neoplasms
dc.subject.meshCell Movement
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFatty Acids, Omega-3
dc.subject.meshFatty Acids, Omega-6
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshNeoplasm Invasiveness
dc.subject.meshProstatic Neoplasms
dc.subject.meshRisk Factors
dc.subject.meshTumor Cells, Cultured
dc.titlePromotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs.en
dc.typeArticleen
dc.contributor.departmentProMPT Genito Urinary Cancer Research Group, Cancer Research UK. mbrown@picr.man.ac.uken
dc.identifier.journalBritish Journal of Canceren
html.description.abstractEpidemiological studies have shown not only a relationship between the intake of dietary lipids and an increased risk of developing metastatic prostate cancer, but also the type of lipid intake that influences the risk of metastatic prostate cancer. The Omega-6 poly-unsaturated fatty acid, Arachidonic acid, has been shown to enhance the proliferation of malignant prostate epithelial cells and increase the risk of advanced prostate cancer. However, its role in potentiating the migration of cancer cells is unknown. Here we show that arachidonic acid at concentrations <or=5 microM is a potent stimulator of malignant epithelial cellular invasion, which is able to restore invasion toward hydrocortisone-deprived adipocyte-free human bone marrow stroma completely. This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398. These results identify a mechanism by which arachidonic acid may potentiate the risk of metastatic migration and secondary implantation in vivo, a risk which can be reduced with the uptake of Omega-3 poly-unsaturated fatty acids.


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