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    Imaging vascular physiology to monitor cancer treatment.

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    Authors
    Laking, George R
    West, Catharine M L
    Buckley, David L
    Matthews, Julian C
    Price, Patricia M
    Affiliation
    Cancer Research UK PET Oncology Group, University of Manchester, Wolfson Molecular Imaging Centre, Manchester M203LJ, UK. george.laking@manchester.ac.uk
    Issue Date
    2006-05
    
    Metadata
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    Abstract
    The primary physiological function of the vasculature is to support perfusion, the nutritive flow of blood through the tissues. Vascular physiology can be studied non-invasively in human subjects using imaging methods such as positron emission tomography (PET), magnetic resonance imaging (MRI), X-ray computed tomography (CT), and Doppler ultrasound (DU). We describe the physiological rationale for imaging vascular physiology with these methods. We review the published data on repeatability. We review the literature on 'before-and-after' studies using these methods to monitor response to treatment in human subjects, in five broad clinical settings: (1) antiangiogenic agents, (2) vascular disruptive agents, (3) conventional cytotoxic drugs, (4) radiation treatment, and (5) agents affecting drug delivery. We argue that imaging of vascular physiology offers an attractive 'functional endpoint' for clinical trials of anticancer treatment. More conventional measures of tumour response, such as size criteria and the uptake of fluorodeoxyglucose, may be insensitive to therapeutically important changes in vascular function.
    Citation
    Imaging vascular physiology to monitor cancer treatment. 2006, 58 (2):95-113 Crit. Rev. Oncol. Hematol.
    Journal
    Critical Reviews in Oncology/Hematology
    URI
    http://hdl.handle.net/10541/72861
    DOI
    10.1016/j.critrevonc.2005.10.006
    PubMed ID
    16387510
    Type
    Article
    Language
    en
    ISSN
    1040-8428
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.critrevonc.2005.10.006
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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