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    A correlation of FTIR spectra derived from prostate cancer biopsies with gleason grade and tumour stage.

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    Authors
    Gazi, Ehsan
    Baker, Matthew J
    Dwyer, John
    Lockyer, Nicholas P
    Gardner, Peter
    Shanks, Jonathan H
    Reeve, Roy S
    Hart, Claire A
    Clarke, Noel W
    Brown, Michael D
    Affiliation
    School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, UK. EGazi@picr.man.ac.uk
    Issue Date
    2006-10
    
    Metadata
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    Abstract
    OBJECTIVES: We introduce biochemistry as a second dimension to Gleason grading, using Fourier transform infrared (FTIR) microspectroscopy. For the first time, we correlate FTIR spectra derived from prostate cancer (pCA) tissue with Gleason score and the clinical stage of the tumour at time of biopsy. METHODS: Serial sections from paraffin-embedded pCA tissue were collected. One was stained with hematoxylin and eosin and Gleason scored; FTIR spectra were collected from malignant locations using a second unstained section. FTIR spectra, representing different Gleason grades, were used to construct a diagnostic classifier for pCA using linear discriminant analysis (LDA). This model was blind tested using 383 IR spectra from 36 biopsies. RESULTS: Using a three-band Gleason criteria, we obtained sensitivity of > or =70% for the FTIR-LDA model to predict Gleason <7,=7, and >7, with specificities of > or =81%. Using a threshold of Gleason/FTIR-LDA score of > or =8, we obtained a sensitivity and specificity of 71% and 67%, respectively, for the correlation with metastatic tumours using the FTIR-LDA system and 85% and 63%, respectively, for the correlation of metastatic tumours using the Gleason system. CONCLUSIONS: There is a correlation between tissue architecture using Gleason score with tissue biochemistry using FTIR-LDA. Both systems are similar in their performance in predicting metastatic behaviour in tumours from individual patients.
    Citation
    A correlation of FTIR spectra derived from prostate cancer biopsies with gleason grade and tumour stage. 2006, 50 (4):750-60; discussion 760-1 Eur. Urol.
    Journal
    European Urology
    URI
    http://hdl.handle.net/10541/72858
    DOI
    10.1016/j.eururo.2006.03.031
    PubMed ID
    16632188
    Type
    Article
    Language
    en
    ISSN
    0302-2838
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.eururo.2006.03.031
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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