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    A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis.

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    Authors
    Baka, Sofia
    Clamp, Andrew R
    Jayson, Gordon C
    Affiliation
    Christie Hospital, Manchester, M20 4BX, UK. bakasofia@hotmail.com
    Issue Date
    2006-12
    
    Metadata
    Show full item record
    Abstract
    Angiogenesis plays an important role in the formation of new blood vessels and is crucial for tumour development and progression. Imbalance between pro- and antiangiogenesis factors regulates the biological process of angiogenesis. The best characterised of the proangiogenic factors and the most potent is vascular endothelial growth factor (VEGF). The binding of VEGF to one of its transmembrane tyrosine kinase receptors, which are predominantly found on endothelial cells, results in receptor dimerisation, activation and autophosphorylation of the tyrosine kinase domain. This triggers a cascade of complex downstream signalling pathways. Several strategies targeting the VEGF signalling pathway have been developed. These include neutralising antibodies to VEGF (bevacizumab) or VEGF receptors (VEGFRs) (DC101), soluble VEGFR/VEGFR hybrids (VEGF-Trap), and tyrosine kinase inhibitors of VEGFRs (BAY43-9006, SU11248, ZD6474, AZD2171, PTK/ZK and others). Several of these agents are now being investigated in clinical trials.
    Citation
    A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis. 2006, 10 (6):867-76 Expert Opin. Ther. Targets
    Journal
    Expert Opinion on Therapeutic Targets
    URI
    http://hdl.handle.net/10541/72854
    DOI
    10.1517/14728222.10.6.867
    PubMed ID
    17105373
    Type
    Article
    Language
    en
    ISSN
    1744-7631
    ae974a485f413a2113503eed53cd6c53
    10.1517/14728222.10.6.867
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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