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    Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers.

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    Authors
    Winter, Stuart C
    Buffa, Francesca M
    Silva, Priyamal
    Miller, Crispin J
    Valentine, Helen R
    Turley, Helen
    Shah, Ketan A
    Cox, Graham J
    Corbridge, Rogan J
    Homer, Jarrod J
    Musgrove, Brian
    Slevin, Nicholas J
    Sloan, Philip
    Price, Patricia M
    West, Catharine M L
    Harris, Adrian L
    Show allShow less
    Affiliation
    Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital.
    Issue Date
    2007-04-01
    
    Metadata
    Show full item record
    Abstract
    Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g., CA9, GLUT1, and VEGF). To minimize random aggregation, strongly correlated up-regulated genes appearing in >50% of clusters defined a signature comprising 99 genes, of which 27% were previously known to be hypoxia associated. The median RNA expression of the 99 genes in the signature was an independent prognostic factor for recurrence-free survival in a publicly available head and neck cancer data set, outdoing the original intrinsic classifier. In a published breast cancer series, the hypoxia signature was a significant prognostic factor for overall survival independent of clinicopathologic risk factors and a trained profile. The work highlights the validity and potential of using data from analysis of in vitro stress pathways for deriving a biological metagene/gene signature in vivo.
    Citation
    Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. 2007, 67 (7):3441-9 Cancer Res.
    Journal
    Cancer Research
    URI
    http://hdl.handle.net/10541/72842
    DOI
    10.1158/0008-5472.CAN-06-3322
    PubMed ID
    17409455
    Type
    Article
    Language
    en
    ISSN
    0008-5472
    ae974a485f413a2113503eed53cd6c53
    10.1158/0008-5472.CAN-06-3322
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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