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    Stage- and CA125-related survival in patients with epithelial ovarian cancer treated at a cancer center.

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    Authors
    Board, Ruth E
    Bruijns, C T P H
    Pronk, A E
    Ryder, W David J
    Wilkinson, Peter M
    Welch, Richard
    Shanks, Jonathan H
    Connolly, G
    Slade, Richard J
    Reynolds, K
    Kitchener, Henry C
    Jayson, Gordon C
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    Affiliation
    Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom. ruth.board@christie-tr.nwest.nhs.uk
    Issue Date
    2006
    
    Metadata
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    Abstract
    Current accepted prognostic indicators in ovarian cancer include performance status, surgical (FIGO) staging, and residual disease after operation. Here we present data from a prospective analysis of patients with ovarian cancer treated at the Christie Hospital. We confirm the independent prognostic effects of FIGO staging, performance status, and residual disease in our group of patients and furthermore show that CA125 levels at presentation to the oncology service are of independent prognostic significance (P= 0.02). We present survival data and show that the 3-year, cancer-specific survival for stage I disease is 90%. We postulate that this good survival may in part be due to the use of computed tomography scanning at presentation to allow accurate staging. Further clinical trials are needed to test whether combinations of surgical, histologic, biochemical, and radiologic parameters can be used to identify a population with such a good prognosis that adjuvant therapy is not required.
    Citation
    Stage- and CA125-related survival in patients with epithelial ovarian cancer treated at a cancer center., 16 Suppl 1:18-24 Int. J. Gynecol. Cancer
    Journal
    International Journal of Gynecological Cancer
    URI
    http://hdl.handle.net/10541/72837
    DOI
    10.1111/j.1525-1438.2006.00308.x
    PubMed ID
    16515562
    Type
    Article
    Language
    en
    ISSN
    1048-891X
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1525-1438.2006.00308.x
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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