Stage- and CA125-related survival in patients with epithelial ovarian cancer treated at a cancer center.
AuthorsBoard, Ruth E
Bruijns, C T P H
Pronk, A E
Ryder, W David J
Wilkinson, Peter M
Shanks, Jonathan H
Slade, Richard J
Kitchener, Henry C
Jayson, Gordon C
AffiliationCancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom. firstname.lastname@example.org
MetadataShow full item record
AbstractCurrent accepted prognostic indicators in ovarian cancer include performance status, surgical (FIGO) staging, and residual disease after operation. Here we present data from a prospective analysis of patients with ovarian cancer treated at the Christie Hospital. We confirm the independent prognostic effects of FIGO staging, performance status, and residual disease in our group of patients and furthermore show that CA125 levels at presentation to the oncology service are of independent prognostic significance (P= 0.02). We present survival data and show that the 3-year, cancer-specific survival for stage I disease is 90%. We postulate that this good survival may in part be due to the use of computed tomography scanning at presentation to allow accurate staging. Further clinical trials are needed to test whether combinations of surgical, histologic, biochemical, and radiologic parameters can be used to identify a population with such a good prognosis that adjuvant therapy is not required.
CitationStage- and CA125-related survival in patients with epithelial ovarian cancer treated at a cancer center., 16 Suppl 1:18-24 Int. J. Gynecol. Cancer
JournalInternational Journal of Gynecological Cancer
- Significance of serum CA125 and TPS antigen levels for determination of overall survival after three chemotherapy courses in ovarian cancer patients during long-term follow-up.
- Authors: van Dalen A, Favier J, Hallensleben E, Burges A, Stieber P, de Bruijn HW, Fink D, Ferrero A, McGing P, Harlozinska A, Kainz Ch, Markowska J, Molina R, Sturgeon C, Bowman A, Einarsson R, Goike H
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- High levels of pretreatment CA125 are associated to improved survival in high grade serous ovarian carcinoma.
- Authors: Morales-Vásquez F, Pedernera E, Reynaga-Obregón J, López-Basave HN, Gómora MJ, Carlón E, Cárdenas S, Silva-Ayala R, Almaraz M, Méndez C
- Issue date: 2016 Jul 7
- Preoperative serum CA125 levels do not predict suboptimal cytoreductive surgery in epithelial ovarian cancer.
- Authors: Arits AH, Stoot JE, Botterweck AA, Roumen FJ, Voogd AC
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- [Prognostic value of serum CA(125) level change during chemotherapy post-surgery in patients with advanced epithelial ovarian carcinoma].
- Authors: Lan CY, Huang H, Liu JH
- Issue date: 2008 Oct
- Preoperative CA 125: an independent prognostic factor in patients with stage I epithelial ovarian cancer.
- Authors: Nagele F, Petru E, Medl M, Kainz C, Graf AH, Sevelda P
- Issue date: 1995 Aug
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