AffiliationBreast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.
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AbstractRecent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.
CitationBreast stem cells and cancer. 2006 (5):141-53 Ernst Schering Found Symp Proc
JournalErnst Schering Foundation Symposium Proceedings
- Mammary stem cells and breast cancer--role of Notch signalling.
- Authors: Farnie G, Clarke RB
- Issue date: 2007 Jun
- Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.
- Authors: Farnie G, Clarke RB, Spence K, Pinnock N, Brennan K, Anderson NG, Bundred NJ
- Issue date: 2007 Apr 18
- Stem cells in normal breast development and breast cancer.
- Authors: Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS
- Issue date: 2003 Oct
- Human breast epithelial stem cells and their regulation.
- Authors: Kalirai H, Clarke RB
- Issue date: 2006 Jan
- Mammary gland stem cells: current status and future challenges.
- Authors: Fridriksdottir AJ, Petersen OW, Rønnov-Jessen L
- Issue date: 2011