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    Breast stem cells and cancer.

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    Authors
    Farnie, Gillian
    Clarke, Robert B
    Affiliation
    Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.
    Issue Date
    2006
    
    Metadata
    Show full item record
    Abstract
    Recent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.
    Citation
    Breast stem cells and cancer. 2006 (5):141-53 Ernst Schering Found Symp Proc
    Journal
    Ernst Schering Foundation Symposium Proceedings
    URI
    http://hdl.handle.net/10541/72747
    DOI
    10.1007/2789_2007_049
    PubMed ID
    17939300
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/2789_2007_049
    Scopus Count
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    All Paterson Institute for Cancer Research

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