Affiliation
Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.Issue Date
2006
Metadata
Show full item recordAbstract
Recent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.Citation
Breast stem cells and cancer. 2006 (5):141-53 Ernst Schering Found Symp ProcJournal
Ernst Schering Foundation Symposium ProceedingsDOI
10.1007/2789_2007_049PubMed ID
17939300Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1007/2789_2007_049