Show simple item record

dc.contributor.authorSims, Andrew H
dc.contributor.authorOng, Kai Ren
dc.contributor.authorClarke, Robert B
dc.contributor.authorHowell, Anthony
dc.date.accessioned2009-07-07T11:22:35Z
dc.date.available2009-07-07T11:22:35Z
dc.date.issued2006
dc.identifier.citationHigh-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? 2006, 8 (5):214 Breast Cancer Res.en
dc.identifier.issn1465-542X
dc.identifier.pmid17076877
dc.identifier.doi10.1186/bcr1605
dc.identifier.urihttp://hdl.handle.net/10541/72739
dc.description.abstractGene expression profiling is a relatively new technology for the study of breast cancers, but within the past few years there has been a rapid rise in interest in its potential to improve the clinical management of breast cancer. This technology has contributed to our knowledge of the molecular pathology of breast tumours and shows promise as a tool to predict response to therapy and outcome, such as risk of metastasis. Microarray technology is continually developing and it is becoming apparent that, despite the various platforms available, robust conclusions can still be drawn that apply across the different array types. Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms
dc.subject.meshClinical Trials as Topic
dc.subject.meshCost-Benefit Analysis
dc.subject.meshFemale
dc.subject.meshGene Expression Profiling
dc.subject.meshHumans
dc.subject.meshOligonucleotide Array Sequence Analysis
dc.subject.meshPrognosis
dc.subject.meshTechnology Transfer
dc.titleHigh-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.en
dc.identifier.journalBreast Cancer Researchen
html.description.abstractGene expression profiling is a relatively new technology for the study of breast cancers, but within the past few years there has been a rapid rise in interest in its potential to improve the clinical management of breast cancer. This technology has contributed to our knowledge of the molecular pathology of breast tumours and shows promise as a tool to predict response to therapy and outcome, such as risk of metastasis. Microarray technology is continually developing and it is becoming apparent that, despite the various platforms available, robust conclusions can still be drawn that apply across the different array types. Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool.


This item appears in the following Collection(s)

Show simple item record