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    High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

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    Authors
    Sims, Andrew H
    Ong, Kai Ren
    Clarke, Robert B
    Howell, Anthony
    Affiliation
    Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.
    Issue Date
    2006
    
    Metadata
    Show full item record
    Abstract
    Gene expression profiling is a relatively new technology for the study of breast cancers, but within the past few years there has been a rapid rise in interest in its potential to improve the clinical management of breast cancer. This technology has contributed to our knowledge of the molecular pathology of breast tumours and shows promise as a tool to predict response to therapy and outcome, such as risk of metastasis. Microarray technology is continually developing and it is becoming apparent that, despite the various platforms available, robust conclusions can still be drawn that apply across the different array types. Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool.
    Citation
    High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic? 2006, 8 (5):214 Breast Cancer Res.
    Journal
    Breast Cancer Research
    URI
    http://hdl.handle.net/10541/72739
    DOI
    10.1186/bcr1605
    PubMed ID
    17076877
    Type
    Article
    Language
    en
    ISSN
    1465-542X
    ae974a485f413a2113503eed53cd6c53
    10.1186/bcr1605
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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