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dc.contributor.authorKalirai, Helen
dc.contributor.authorClarke, Robert B
dc.date.accessioned2009-07-07T10:03:36Z
dc.date.available2009-07-07T10:03:36Z
dc.date.issued2006-01
dc.identifier.citationHuman breast epithelial stem cells and their regulation. 2006, 208 (1):7-16 J. Pathol.en
dc.identifier.issn0022-3417
dc.identifier.pmid16294373
dc.identifier.doi10.1002/path.1881
dc.identifier.urihttp://hdl.handle.net/10541/72713
dc.description.abstractThis review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Genesen
dc.subject.meshAdult
dc.subject.meshBreast
dc.subject.meshBreast Neoplasms
dc.subject.meshCell Division
dc.subject.meshEpithelial Cells
dc.subject.meshEstrogen Receptor alpha
dc.subject.meshFemale
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshGenes, Neoplasm
dc.subject.meshHumans
dc.subject.meshMammary Glands, Human
dc.subject.meshModels, Biological
dc.subject.meshSignal Transduction
dc.subject.meshStem Cells
dc.titleHuman breast epithelial stem cells and their regulation.en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK.en
dc.identifier.journalThe Journal of Pathologyen
html.description.abstractThis review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours.


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