• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Multiprotein signalling complexes: regional assembly on heparan sulphate.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Gallagher, John T
    Affiliation
    CRUK Department of Medical Oncology, University of Manchester, Paterson Institute for Cancer Research, UK. jgallagher@picr.man.ac.uk
    Issue Date
    2006-06
    
    Metadata
    Show full item record
    Abstract
    Heparan sulphate (HS) is an abundant component of cell surfaces and the extracellular matrix. It binds to a wide variety of peptide growth factors, morphogens, chemokines and extracellular matrix proteins (e.g. fibronectin) and many of these interactions are essential for these effector proteins to transduce signals across the plasma membrane. The unique molecular design and flexibility of HS are essential for its ability to exert control over the cellular response to proteinaceous ligands. The clustering of sulphated sugar residues in a series of complex domains with variable sulphation patterns generates considerable diversity in the molecular fine structure of HS. This diversity reflects a high degree of selectivity in protein recognition and in the assembly of functional multiprotein complexes on the HS polymer chain.
    Citation
    Multiprotein signalling complexes: regional assembly on heparan sulphate. 2006, 34 (Pt 3):438-41 Biochem. Soc. Trans.
    Journal
    Biochemical Society Transactions
    URI
    http://hdl.handle.net/10541/72683
    DOI
    10.1042/BST0340438
    PubMed ID
    16709181
    Type
    Article
    Language
    en
    ISSN
    0300-5127
    ae974a485f413a2113503eed53cd6c53
    10.1042/BST0340438
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator.
    • Authors: Hu Y, González-Martínez D, Kim SH, Bouloux PM
    • Issue date: 2004 Dec 15
    • Insights into the role of heparan sulphate in fibroblast growth factor signalling.
    • Authors: Harmer NJ
    • Issue date: 2006 Jun
    • Heparan sulfate-protein interactions--a concept for drug design?
    • Authors: Lindahl U
    • Issue date: 2007 Jul
    • Heparan sulphates as membrane receptors for the fibroblast growth factors.
    • Authors: Gallagher JT
    • Issue date: 1994 Apr
    • The molecular basis and functional implications of chemokine interactions with heparan sulphate.
    • Authors: Lortat-Jacob H
    • Issue date: 2009 Oct
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.