Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.
Affiliation
Cancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.ukIssue Date
2006-04
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We show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.Citation
Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18. 2006, 64 (4):431-4 Appl Radiat IsotJournal
Applied Radiation and IsotopesDOI
10.1016/j.apradiso.2005.08.008PubMed ID
16290946Type
ArticleLanguage
enISSN
0969-8043ae974a485f413a2113503eed53cd6c53
10.1016/j.apradiso.2005.08.008
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