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    Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.

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    Authors
    Gillies, James M
    Najim, N
    Zweit, Jamal
    Affiliation
    Cancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.uk
    Issue Date
    2006-04
    
    Metadata
    Show full item record
    Abstract
    We show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.
    Citation
    Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18. 2006, 64 (4):431-4 Appl Radiat Isot
    Journal
    Applied Radiation and Isotopes
    URI
    http://hdl.handle.net/10541/72681
    DOI
    10.1016/j.apradiso.2005.08.008
    PubMed ID
    16290946
    Type
    Article
    Language
    en
    ISSN
    0969-8043
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.apradiso.2005.08.008
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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