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    Alpha-v integrins as therapeutic targets in oncology.

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    Authors
    Nemeth, Jeffrey A
    Nakada, Marian T
    Trikha, M
    Lang, Zhihui
    Gordon, Michael S
    Jayson, Gordon C
    Corringham, Robert E
    Prabhakar, Uma
    Davis, Hugh M
    Beckman, Robert A
    Affiliation
    Centocor, Inc., Radnor, Pennsylvania 19087, USA. jnemeth@cntus.jnj.com
    Issue Date
    2007-10
    
    Metadata
    Show full item record
    Abstract
    Integrins are heterodimeric cell adhesion receptors that mediate intercellular communication through cell-extracellular matrix interactions and cell-cell interactions. Integrins have been demonstrated to play a direct role in cancer progression, specifically in tumor cell survival, tumor angiogenesis, and metastasis. Therefore, agents targeted against integrin function have potential as effective anticancer therapies. Numerous anti-integrin agents, including monoclonal antibodies and small-molecule inhibitors, are in clinical development for the treatment of solid and hematologic tumors. This review focuses on the role of alpha(v) integrins in cancer progression, the current status of integrin-targeted agents in development, and strategies for the clinical development of anti-integrin therapies.
    Citation
    Alpha-v integrins as therapeutic targets in oncology. 2007, 25 (7):632-46 Cancer Invest.
    Journal
    Cancer Investigation
    URI
    http://hdl.handle.net/10541/72673
    DOI
    10.1080/07357900701522638
    PubMed ID
    18027153
    Type
    Article
    Language
    en
    ISSN
    1532-4192
    ae974a485f413a2113503eed53cd6c53
    10.1080/07357900701522638
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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