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dc.contributor.authorMaurice, Andrew
dc.contributor.authorEvans, D Gareth R
dc.contributor.authorShenton, Andrew
dc.contributor.authorAshcroft, Linda
dc.contributor.authorBaildam, Andrew D
dc.contributor.authorBarr, Lester
dc.contributor.authorByrne, Ged J
dc.contributor.authorBundred, Nigel J
dc.contributor.authorBoggis, C
dc.contributor.authorWilson, M
dc.contributor.authorDuffy, Stephen W
dc.contributor.authorHowell, Anthony
dc.date.accessioned2009-07-06T16:52:30Z
dc.date.available2009-07-06T16:52:30Z
dc.date.issued2006-07
dc.identifier.citationScreening younger women with a family history of breast cancer--does early detection improve outcome? 2006, 42 (10):1385-90 Eur. J. Canceren
dc.identifier.issn0959-8049
dc.identifier.pmid16750910
dc.identifier.doi10.1016/j.ejca.2006.01.055
dc.identifier.urihttp://hdl.handle.net/10541/72656
dc.description.abstractWomen with a family history are often offered mammographic surveillance at an earlier age and with greater frequency than those in the National Breast Screening Programme. In this study, we compared the survival of 62 breast cancer patients diagnosed in the context of a family history clinic offering 12-18 monthly mammographic screening with that of 1108 patients of the same age range but having no exposure to screening. We subtracted the expected additional observation time due to lead time from the survival of the screen-detected cases. Survival was significantly better in the family history group with relative hazards of 0.19 (95% CI 0.07-0.52, P<0.001) for breast cancer death and 0.19 (95% CI 0.08-0.43, P<0.001) for disease-free survival. After correcting for lead-time, the relative hazards were 0.24 (95% CI 0.09-0.66, P=0.005) for breast cancer death and 0.25 (95% CI 0.11-0.57, P<0.001) for disease-free survival. These results strongly suggest that screening younger women with a family history of breast cancer leads to improved survival. More precise estimates of the benefit will accrue from further follow-up and other such studies.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult
dc.subject.meshBreast Neoplasms
dc.subject.meshEarly Diagnosis
dc.subject.meshFemale
dc.subject.meshGenes, BRCA1
dc.subject.meshGenes, BRCA2
dc.subject.meshGenetic Screening
dc.subject.meshHeterozygote
dc.subject.meshHumans
dc.subject.meshMammography
dc.subject.meshMiddle Aged
dc.subject.meshPedigree
dc.subject.meshSurvival Analysis
dc.subject.meshTreatment Outcome
dc.titleScreening younger women with a family history of breast cancer--does early detection improve outcome?en
dc.typeArticleen
dc.contributor.departmentBreast Cancer Family History Clinic, Nightingale Centre, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK.en
dc.identifier.journalEuropean Journal of Canceren
html.description.abstractWomen with a family history are often offered mammographic surveillance at an earlier age and with greater frequency than those in the National Breast Screening Programme. In this study, we compared the survival of 62 breast cancer patients diagnosed in the context of a family history clinic offering 12-18 monthly mammographic screening with that of 1108 patients of the same age range but having no exposure to screening. We subtracted the expected additional observation time due to lead time from the survival of the screen-detected cases. Survival was significantly better in the family history group with relative hazards of 0.19 (95% CI 0.07-0.52, P<0.001) for breast cancer death and 0.19 (95% CI 0.08-0.43, P<0.001) for disease-free survival. After correcting for lead-time, the relative hazards were 0.24 (95% CI 0.09-0.66, P=0.005) for breast cancer death and 0.25 (95% CI 0.11-0.57, P<0.001) for disease-free survival. These results strongly suggest that screening younger women with a family history of breast cancer leads to improved survival. More precise estimates of the benefit will accrue from further follow-up and other such studies.


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