Screening younger women with a family history of breast cancer--does early detection improve outcome?
Evans, D Gareth R
Baildam, Andrew D
Byrne, Ged J
Bundred, Nigel J
Duffy, Stephen W
AffiliationBreast Cancer Family History Clinic, Nightingale Centre, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK.
MetadataShow full item record
AbstractWomen with a family history are often offered mammographic surveillance at an earlier age and with greater frequency than those in the National Breast Screening Programme. In this study, we compared the survival of 62 breast cancer patients diagnosed in the context of a family history clinic offering 12-18 monthly mammographic screening with that of 1108 patients of the same age range but having no exposure to screening. We subtracted the expected additional observation time due to lead time from the survival of the screen-detected cases. Survival was significantly better in the family history group with relative hazards of 0.19 (95% CI 0.07-0.52, P<0.001) for breast cancer death and 0.19 (95% CI 0.08-0.43, P<0.001) for disease-free survival. After correcting for lead-time, the relative hazards were 0.24 (95% CI 0.09-0.66, P=0.005) for breast cancer death and 0.25 (95% CI 0.11-0.57, P<0.001) for disease-free survival. These results strongly suggest that screening younger women with a family history of breast cancer leads to improved survival. More precise estimates of the benefit will accrue from further follow-up and other such studies.
CitationScreening younger women with a family history of breast cancer--does early detection improve outcome? 2006, 42 (10):1385-90 Eur. J. Cancer
JournalEuropean Journal of Cancer
- Use of intensified early cancer detection in high-risk patients with familial breast and ovarian cancer.
- Authors: Lux MP, Ackermann S, Nestle-Krämling C, Goecke TO, Niederacher D, Bodden-Heidrich R, Bender HG, Beckmann MW, Fasching PA
- Issue date: 2005 Aug
- Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1.
- Authors: Lose F, Duffy DL, Kay GF, Kedda MA, Spurdle AB, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer., Australian Ovarian Cancer Study Management Group.
- Issue date: 2008 Nov 5
- A family history of breast cancer will not predict female early onset breast cancer in a population-based setting.
- Authors: de Bock GH, Jacobi CE, Seynaeve C, Krol-Warmerdam EM, Blom J, van Asperen CJ, Cornelisse CJ, Klijn JG, Devilee P, Tollenaar RA, Brekelmans CT, van Houwelingen JC
- Issue date: 2008 Jul 23
- Screen positive rates among six family history screening protocols for breast/ovarian cancer in four cohorts of women.
- Authors: McClain MR, Palomaki GE, Hampel H, Westman JA, Haddow JE
- Issue date: 2008
- Validation of a tool for identifying women at high risk for hereditary breast cancer in population-based screening.
- Authors: Hoskins KF, Zwaagstra A, Ranz M
- Issue date: 2006 Oct 15