Screening younger women with a family history of breast cancer--does early detection improve outcome?
Authors
Maurice, AndrewEvans, D Gareth R
Shenton, Andrew
Ashcroft, Linda
Baildam, Andrew D
Barr, Lester
Byrne, Ged J
Bundred, Nigel J
Boggis, C
Wilson, M
Duffy, Stephen W
Howell, Anthony
Affiliation
Breast Cancer Family History Clinic, Nightingale Centre, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK.Issue Date
2006-07
Metadata
Show full item recordAbstract
Women with a family history are often offered mammographic surveillance at an earlier age and with greater frequency than those in the National Breast Screening Programme. In this study, we compared the survival of 62 breast cancer patients diagnosed in the context of a family history clinic offering 12-18 monthly mammographic screening with that of 1108 patients of the same age range but having no exposure to screening. We subtracted the expected additional observation time due to lead time from the survival of the screen-detected cases. Survival was significantly better in the family history group with relative hazards of 0.19 (95% CI 0.07-0.52, P<0.001) for breast cancer death and 0.19 (95% CI 0.08-0.43, P<0.001) for disease-free survival. After correcting for lead-time, the relative hazards were 0.24 (95% CI 0.09-0.66, P=0.005) for breast cancer death and 0.25 (95% CI 0.11-0.57, P<0.001) for disease-free survival. These results strongly suggest that screening younger women with a family history of breast cancer leads to improved survival. More precise estimates of the benefit will accrue from further follow-up and other such studies.Citation
Screening younger women with a family history of breast cancer--does early detection improve outcome? 2006, 42 (10):1385-90 Eur. J. CancerJournal
European Journal of CancerDOI
10.1016/j.ejca.2006.01.055PubMed ID
16750910Type
ArticleLanguage
enISSN
0959-8049ae974a485f413a2113503eed53cd6c53
10.1016/j.ejca.2006.01.055
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