• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Woodhouse, Linda J
    Mukherjee, Annice
    Shalet, Stephen M
    Ezzat, Shereen
    Affiliation
    School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
    Issue Date
    2006-05
    
    Metadata
    Show full item record
    Abstract
    The availability of recombinant human GH and somatostatin analogs has resulted in widespread treatment for adults with GH deficiency (GHD) and those with GH excess (acromegaly). Despite being at opposite ends of the spectrum in terms of their GH/IGF-I axis, both of these populations experience overlapping somatic impairments. Adults with untreated GHD have low circulating levels of IGF-I that manifest as altered body composition with increased fat and reduced lean body and skeletal muscle mass. At the other end of the spectrum, adults with GH excess, who have elevated levels of IGF-I, also have altered body composition. Impairments that result from disorders of either GHD or GH excess are both associated with increased functional limitations, such as reduced ability to walk quickly for prolonged periods, and poorer health-related quality of life (HR-QoL). Adults with untreated GHD and GH excess both commonly complain of excessive fatigue that seems to be associated more with impaired aerobic than muscular performance. Several studies have documented that administration of GH or somatostatin analogs to adults with GHD or GH excess, respectively, ameliorates abnormal biochemical profile and the associated somatic impairments. However, whether these improvements translate into improved physical function in adults with GHD or GH excess remains largely unknown, and their impact on HR-QoL controversial. Review of placebo-controlled trials to date suggests that GH and somatostatin analogs have greater effects on gas exchange and aerobic performance than as anabolic agents on skeletal muscle mass and function. Future investigations should include dose-response studies to establish the optimal combination of pharmacological agents plus exercise required to improve not only biochemical markers but also physical function and HR-QoL in adults with GHD or GH excess.
    Citation
    The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. 2006, 27 (3):287-317 Endocr. Rev.
    Journal
    Endocrine Reviews
    URI
    http://hdl.handle.net/10541/72641
    DOI
    10.1210/er.2004-0022
    PubMed ID
    16543384
    Type
    Article
    Language
    en
    ISSN
    0163-769X
    ae974a485f413a2113503eed53cd6c53
    10.1210/er.2004-0022
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Effect of growth hormone therapy and puberty on bone and body composition in children with idiopathic short stature and growth hormone deficiency.
    • Authors: Högler W, Briody J, Moore B, Lu PW, Cowell CT
    • Issue date: 2005 Nov
    • Safety and efficacy of growth hormone (GH) during extended treatment of adult Japanese patients with GH deficiency (GHD).
    • Authors: Chihara K, Kato Y, Kohno H, Takano K, Tanaka T, Teramoto A, Shimatsu A
    • Issue date: 2008 Aug
    • Effects of growth hormone replacement on physical performance and body composition in GH deficient adults.
    • Authors: Rodríguez-Arnao J, Jabbar A, Fulcher K, Besser GM, Ross RJ
    • Issue date: 1999 Jul
    • Impact of growth hormone status on body composition and the skeleton.
    • Authors: Mukherjee A, Murray RD, Shalet SM
    • Issue date: 2004
    • Baseline characteristics and the effects of two years of growth hormone (GH) replacement therapy in adults with GH deficiency previously treated for acromegaly.
    • Authors: Norrman LL, Johannsson G, Sunnerhagen KS, Svensson J
    • Issue date: 2008 Jul
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.