Show simple item record

dc.contributor.authorMcBain, Catherine A
dc.contributor.authorHenry, Ann M
dc.contributor.authorSykes, Jonathan R
dc.contributor.authorAmer, Ali M
dc.contributor.authorMarchant, Thomas E
dc.contributor.authorMoore, Christopher J
dc.contributor.authorDavies, Julie
dc.contributor.authorStratford, Julia
dc.contributor.authorMcCarthy, Claire
dc.contributor.authorPorritt, Bridget
dc.contributor.authorWilliams, Peter C
dc.contributor.authorKhoo, Vincent S
dc.contributor.authorPrice, Patricia M
dc.date.accessioned2009-07-06T14:17:25Z
dc.date.available2009-07-06T14:17:25Z
dc.date.issued2006-02-01
dc.identifier.citationX-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging. 2006, 64 (2):625-34 Int. J. Radiat. Oncol. Biol. Phys.en
dc.identifier.issn0360-3016
dc.identifier.pmid16343802
dc.identifier.doi10.1016/j.ijrobp.2005.09.018
dc.identifier.urihttp://hdl.handle.net/10541/72601
dc.description.abstractPURPOSE: X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites. METHODS AND MATERIALS: Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians. RESULTS: X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis. CONCLUSIONS: On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques.
dc.language.isoenen
dc.subjectAbdominal Canceren
dc.subjectCentral Nervous System Canceren
dc.subjectHead and Neck Canceren
dc.subjectPelvic Canceren
dc.subjectThoracic Canceren
dc.subject.meshAbdominal Neoplasms
dc.subject.meshCentral Nervous System Neoplasms
dc.subject.meshFemale
dc.subject.meshHead and Neck Neoplasms
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshNeoplasms
dc.subject.meshPelvic Neoplasms
dc.subject.meshProspective Studies
dc.subject.meshRadiographic Image Interpretation, Computer-Assisted
dc.subject.meshRadiotherapy Dosage
dc.subject.meshRadiotherapy Planning, Computer-Assisted
dc.subject.meshRadiotherapy, Intensity-Modulated
dc.subject.meshThoracic Neoplasms
dc.subject.meshTomography, X-Ray Computed
dc.titleX-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging.en
dc.typeArticleen
dc.contributor.departmentAcademic Department of Radiation Oncology, Christie Hospital NHS Trust, Manchester, England, United Kingdom. catherine.mcbain@christie-tr.nwest.nhs.uken
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen
html.description.abstractPURPOSE: X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites. METHODS AND MATERIALS: Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians. RESULTS: X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis. CONCLUSIONS: On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques.


Files in this item

This item appears in the following Collection(s)

Show simple item record