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    X-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging.

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    Authors
    McBain, Catherine A
    Henry, Ann M
    Sykes, Jonathan R
    Amer, Ali M
    Marchant, Thomas E
    Moore, Christopher J
    Davies, Julie
    Stratford, Julia
    McCarthy, Claire
    Porritt, Bridget
    Williams, Peter C
    Khoo, Vincent S
    Price, Patricia M
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    Affiliation
    Academic Department of Radiation Oncology, Christie Hospital NHS Trust, Manchester, England, United Kingdom. catherine.mcbain@christie-tr.nwest.nhs.uk
    Issue Date
    2006-02-01
    
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    Abstract
    PURPOSE: X-ray volumetric imaging (XVI) for the first time allows for the on-treatment acquisition of three-dimensional (3D) kV cone beam computed tomography (CT) images. Clinical imaging using the Synergy System (Elekta, Crawley, UK) commenced in July 2003. This study evaluated image quality and dose delivered and assessed clinical utility for treatment verification at a range of anatomic sites. METHODS AND MATERIALS: Single XVIs were acquired from 30 patients undergoing radiotherapy for tumors at 10 different anatomic sites. Patients were imaged in their setup position. Radiation doses received were measured using TLDs on the skin surface. The utility of XVI in verifying target volume coverage was qualitatively assessed by experienced clinicians. RESULTS: X-ray volumetric imaging acquisition was completed in the treatment position at all anatomic sites. At sites where a full gantry rotation was not possible, XVIs were reconstructed from projection images acquired from partial rotations. Soft-tissue definition of organ boundaries allowed direct assessment of 3D target volume coverage at all sites. Individual image quality depended on both imaging parameters and patient characteristics. Radiation dose ranged from 0.003 Gy in the head to 0.03 Gy in the pelvis. CONCLUSIONS: On-treatment XVI provided 3D verification images with soft-tissue definition at all anatomic sites at acceptably low radiation doses. This technology sets a new standard in treatment verification and will facilitate novel adaptive radiotherapy techniques.
    Citation
    X-ray volumetric imaging in image-guided radiotherapy: the new standard in on-treatment imaging. 2006, 64 (2):625-34 Int. J. Radiat. Oncol. Biol. Phys.
    Journal
    International Journal of Radiation Oncology, Biology, Physics
    URI
    http://hdl.handle.net/10541/72601
    DOI
    10.1016/j.ijrobp.2005.09.018
    PubMed ID
    16343802
    Type
    Article
    Language
    en
    ISSN
    0360-3016
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijrobp.2005.09.018
    Scopus Count
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