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    Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom.

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    Authors
    Shanley, Susan
    McReynolds, Kate
    Ardern-Jones, Audrey
    Ahern, Roger
    Fernando, Indrajit
    Yarnold, John
    Evans, D Gareth R
    Eccles, Diana
    Hodgson, Shirley V
    Ashley, Sue
    Ashcroft, Linda
    Tutt, Andrew
    Bancroft, Elizabeth
    Short, Susan
    Gui, Gerald
    Barr, Lester
    Baildam, Andrew D
    Howell, Anthony
    Royle, Gavin
    Pierce, Lori
    Easton, Douglas
    Eeles, Rosalind
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    Affiliation
    Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK. Susan.Shanley@rmh.nhs.uk
    Issue Date
    2006-12-01
    
    Metadata
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    Abstract
    PURPOSE: To undertake the first substantial clinical study of breast radiotherapy toxicity in BRCA1 and BRCA2 mutation carriers in the United Kingdom. EXPERIMENTAL DESIGN: Acute and late radiation effects were evaluated in a retrospective study of 55 BRCA1 and BRCA2 mutation carriers treated with radiotherapy for breast cancer at four centers between 1983 and 2002. Individual matching with controls who had sporadic breast cancer was undertaken for age at diagnosis, time since completion of radiation, and treatment variables. Detailed assessments were undertaken by one examiner. Median follow-up was 6.75 years for carriers and 7.75 years for controls. Rates of late events (rib fractures, lung fibrosis, necrosis of soft tissue/bone, and pericarditis) as well as LENT-SOMA scores and clinical photography scores of breast size, shape, and skin telangiectasia were the primary end points. RESULTS: No increase in clinically significant late toxicity was seen in the mutation carriers. CONCLUSIONS: These data add substantial weight to the evidence that the outcomes in the treated breast from radiotherapy in women with BRCA1 or BRCA2 mutations are comparable with those in women with sporadic breast cancer.
    Citation
    Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom. 2006, 12 (23):7025-32 Clin. Cancer Res.
    Journal
    Clinical Cancer Research
    URI
    http://hdl.handle.net/10541/72595
    DOI
    10.1158/1078-0432.CCR-06-1244
    PubMed ID
    17145824
    Type
    Article
    Language
    en
    ISSN
    1078-0432
    ae974a485f413a2113503eed53cd6c53
    10.1158/1078-0432.CCR-06-1244
    Scopus Count
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