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    The putative role of transforming viruses in childhood acute lymphoblastic leukemia.

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    Authors
    MacKenzie, Jane
    Greaves, Mel F
    Eden, Tim O B
    Clayton, Rob A
    Perry, Jacqueline
    Wilson, Katherine S
    Jarrett, Ruth F
    Affiliation
    LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK.
    Issue Date
    2006-02
    
    Metadata
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    Abstract
    Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representational difference analysis (RDA) to examine tumor samples for the presence of exogenous genomes. Twenty RDA experiments were carried out, using four different restriction enzymes, but no exogenous sequences were identified within leukemic cells. These results suggest that it is unlikely that a single, direct transforming agent is involved in the pathogenesis of common acute lymphoblastic leukemia.
    Citation
    The putative role of transforming viruses in childhood acute lymphoblastic leukemia. 2006, 91 (2):240-3 Haematologica
    Journal
    Haematologica
    URI
    http://hdl.handle.net/10541/72583
    PubMed ID
    16461310
    Type
    Article
    Language
    en
    ISSN
    1592-8721
    Collections
    All Christie Publications

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