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    Prospects for the development of long-acting formulations of human somatropin.

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    Authors
    Jostel, Andreas
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, UK.
    Issue Date
    2006
    
    Metadata
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    Abstract
    In healthy humans, growth hormone (GH) is secreted in distinct pulses with an underlying nyctohemeral pattern. Current forms of somatropin replacement are unable to closely mimic such a release pattern, but are still able to exert the beneficial action of GH. A limited number of short-term studies in rodents and humans suggest that longitudinal growth may be superior when somatropin is given with a pulsatile mode of administration, whereas hepatic insulin-like growth factor-I generation and beneficial changes in body composition appear to be equal or even enhanced with continuous somatropin administration.Recent developments in drug delivery technology have allowed the use of slow-release preparations of somatropin in humans. The most successful technology so far has been the encapsulation of somatropin molecules in poly(D,L-lactic-co-glycolic acid) biodegradable microspheres. Pharmacokinetic and pharmacodynamic data have been published on two such preparations; Nutropin Depot((R)) and hGH-Biosphere((R)). The latter has a superior release profile, but outcomes data from multicenter trials in both children and adults have been presented for the former: catch-up growth was observed in children, although to a lesser degree than historic comparative data obtained with the use of daily somatropin injections and the effects on metabolic derangements in GH-deficient patients appeared similar to those observed with daily injections. Improved sustained-release somatropin preparations will need further study of their long-term efficacy, but, if successful, will be highly attractive in terms of patient compliance and convenience.
    Citation
    Prospects for the development of long-acting formulations of human somatropin. 2006, 5 (3):139-45 Treat Endocrinol
    Journal
    Treatments in Endocrinology
    URI
    http://hdl.handle.net/10541/72530
    DOI
    10.2165/00024677-200605030-00002
    PubMed ID
    16677056
    Type
    Article
    Language
    en
    ISSN
    1175-6349
    ae974a485f413a2113503eed53cd6c53
    10.2165/00024677-200605030-00002
    Scopus Count
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