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dc.contributor.authorYamazaki, Kazuto
dc.contributor.authorEyden, Brian P
dc.date.accessioned2009-07-06T08:48:42Z
dc.date.available2009-07-06T08:48:42Z
dc.date.issued2006
dc.identifier.citationAn immunohistochemical and ultrastructural study of pancreatic microcystic serous cyst adenoma with special reference to tumor-associated microvasculature and vascular endothelial growth factor in tumor cells., 30 (1):119-28 Ultrastruct Patholen
dc.identifier.issn1521-0758
dc.identifier.pmid16517478
dc.identifier.doi10.1080/01913120500407960
dc.identifier.urihttp://hdl.handle.net/10541/72525
dc.description.abstractPancreatic microcystic serous cyst adenomas are rare exocrine tumors composed of small cysts lined by glycogen-rich cells. The disease may be sporadic or present as part of von Hippel-Lindau (VHL) syndrome. Four sporadic cases of pancreatic serous cyst adenoma were examined by conventional histological, immunohistochemical, and ultrastructural methods. In the present study, new findings include the immunohistochemical identification of vascular endothelial growth factor (VEGF) and the lack of PDX-1 (putative master transcriptional factor in pancreatic stem cells) in the epithelial tumor cells. Ultrastructurally, many small blood vessels were intimately associated with epithelial tumor cells and adjacent fibroblastic cells. The observations suggest the possibility that VEGF-containing tumor cells act in a paracrine fashion to stimulate neovascularization; that peripheral blood in the vascular lumen might be filtered or processed by the endothelial and epithelial tumor cells; and that filtrates might therefore be stored as serous inclusions. It is hypothesized that pancreatic serous cyst adenomas might be under the abnormal regulation of the VHL gene, just like VHL disease itself and certain types of renal cell carcinoma, showing the distinctive histology of a rich vascularity intimately related to epithelial lining cells of cysts accompanied by stromal fibroblasts/myofibroblasts and collagenous stroma.
dc.language.isoenen
dc.subjectPancreatic Canceren
dc.subjectTumour Markersen
dc.subject.meshAged
dc.subject.meshCystadenoma, Serous
dc.subject.meshFemale
dc.subject.meshHomeodomain Proteins
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMicrocirculation
dc.subject.meshMicroscopy, Electron, Transmission
dc.subject.meshMiddle Aged
dc.subject.meshNeovascularization, Pathologic
dc.subject.meshPancreas
dc.subject.meshPancreatic Neoplasms
dc.subject.meshTrans-Activators
dc.subject.meshTumor Markers, Biological
dc.subject.meshVascular Endothelial Growth Factor A
dc.subject.meshvon Hippel-Lindau Disease
dc.titleAn immunohistochemical and ultrastructural study of pancreatic microcystic serous cyst adenoma with special reference to tumor-associated microvasculature and vascular endothelial growth factor in tumor cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Saiseikai Central Hospital, Tokyo, Japan. kazutoyamazaki@aol.comen
dc.identifier.journalUltrastructural Pathologyen
html.description.abstractPancreatic microcystic serous cyst adenomas are rare exocrine tumors composed of small cysts lined by glycogen-rich cells. The disease may be sporadic or present as part of von Hippel-Lindau (VHL) syndrome. Four sporadic cases of pancreatic serous cyst adenoma were examined by conventional histological, immunohistochemical, and ultrastructural methods. In the present study, new findings include the immunohistochemical identification of vascular endothelial growth factor (VEGF) and the lack of PDX-1 (putative master transcriptional factor in pancreatic stem cells) in the epithelial tumor cells. Ultrastructurally, many small blood vessels were intimately associated with epithelial tumor cells and adjacent fibroblastic cells. The observations suggest the possibility that VEGF-containing tumor cells act in a paracrine fashion to stimulate neovascularization; that peripheral blood in the vascular lumen might be filtered or processed by the endothelial and epithelial tumor cells; and that filtrates might therefore be stored as serous inclusions. It is hypothesized that pancreatic serous cyst adenomas might be under the abnormal regulation of the VHL gene, just like VHL disease itself and certain types of renal cell carcinoma, showing the distinctive histology of a rich vascularity intimately related to epithelial lining cells of cysts accompanied by stromal fibroblasts/myofibroblasts and collagenous stroma.


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