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dc.contributor.authorChanudet, E
dc.contributor.authorZhou, Y
dc.contributor.authorBacon, C M
dc.contributor.authorWotherspoon, A C
dc.contributor.authorMüller-Hermelink, H K
dc.contributor.authorAdam, P
dc.contributor.authorDong, H Y
dc.contributor.authorDe Jong, D
dc.contributor.authorLi, Y
dc.contributor.authorWei, R
dc.contributor.authorGong, X
dc.contributor.authorWu, Q
dc.contributor.authorRanaldi, Renzo
dc.contributor.authorGoteri, G
dc.contributor.authorPileri, S A
dc.contributor.authorYe, Hongtao
dc.contributor.authorHamoudi, Rifat A
dc.contributor.authorLiu, H
dc.contributor.authorRadford, John A
dc.contributor.authorDu, Ming-Qing
dc.date.accessioned2009-07-06T08:44:09Z
dc.date.available2009-07-06T08:44:09Z
dc.date.issued2006-07
dc.identifier.citationChlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions. 2006, 209 (3):344-51 J. Pathol.en
dc.identifier.issn0022-3417
dc.identifier.pmid16583361
dc.identifier.doi10.1002/path.1984
dc.identifier.urihttp://hdl.handle.net/10541/72521
dc.description.abstractInfectious agents play a critical role in MALT lymphoma development. Studies from Italy showed Chlamydia psittaci infection in 87% of ocular adnexal MALT lymphomas and complete or partial regression of the lymphoma after C. psittaci eradication in four of nine cases. However, C. psittaci was not demonstrated in ocular adnexal MALT lymphomas from the USA. This study was thus designed to investigate further the role of C. psittaci, and other infectious agents commonly associated with chronic eye disease, in the development of ocular adnexal MALT lymphoma. The presence of C. psittaci, C. trachomatis, C. pneumoniae, herpes simplex virus 1 and 2 (HSV1, HSV2), and adenovirus 8 and 19 (ADV8, ADV19) was assessed separately by polymerase chain reaction in 142 ocular adnexal MALT lymphomas, 53 non-marginal zone lymphomas, and 51 ocular adnexal biopsies without a lymphoproliferative disorder (LPD), from six geographical regions. C. psittaci was detected at similar low frequencies in non-LPD and non-marginal zone lymphoma groups from different geographical regions (0-14%). Overall, the prevalence of C. psittaci was significantly higher in MALT lymphomas (22%) than in non-LPD (10%, p=0.042) and non-marginal zone lymphoma cases (9%, p=0.033). However, the prevalence of C. psittaci infection in MALT lymphoma showed marked variation among the six geographical regions examined, being most frequent in Germany (47%), followed by the East Coast of the USA (35%) and the Netherlands (29%), but relatively low in Italy (13%), the UK (12%), and Southern China (11%). No significant differences in the detection of C. pneumoniae, C. trachomatis, HSV1, HSV2, ADV8, and ADV19 were found between lymphomas and controls from different geographical regions. In conclusion, our results show that C. psittaci, but not C. pneumoniae, C. trachomatis, HSV1, HSV2, ADV8 or ADV19, is associated with ocular adnexal MALT lymphoma and that this association is variable in different geographical areas.
dc.language.isoenen
dc.subjectEye Canceren
dc.subjectOrbital Canceren
dc.subject.meshAdenoviridae
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshChild
dc.subject.meshChlamydia trachomatis
dc.subject.meshChlamydophila pneumoniae
dc.subject.meshChlamydophila psittaci
dc.subject.meshEye Neoplasms
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphoma, B-Cell, Marginal Zone
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshPsittacosis
dc.subject.meshRetrospective Studies
dc.subject.meshSimplexvirus
dc.titleChlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University of Cambridge, UK, and Nanfang Hospital, Southern Medical University, Guangzhou, China.en
dc.identifier.journalThe Journal of Pathologyen
html.description.abstractInfectious agents play a critical role in MALT lymphoma development. Studies from Italy showed Chlamydia psittaci infection in 87% of ocular adnexal MALT lymphomas and complete or partial regression of the lymphoma after C. psittaci eradication in four of nine cases. However, C. psittaci was not demonstrated in ocular adnexal MALT lymphomas from the USA. This study was thus designed to investigate further the role of C. psittaci, and other infectious agents commonly associated with chronic eye disease, in the development of ocular adnexal MALT lymphoma. The presence of C. psittaci, C. trachomatis, C. pneumoniae, herpes simplex virus 1 and 2 (HSV1, HSV2), and adenovirus 8 and 19 (ADV8, ADV19) was assessed separately by polymerase chain reaction in 142 ocular adnexal MALT lymphomas, 53 non-marginal zone lymphomas, and 51 ocular adnexal biopsies without a lymphoproliferative disorder (LPD), from six geographical regions. C. psittaci was detected at similar low frequencies in non-LPD and non-marginal zone lymphoma groups from different geographical regions (0-14%). Overall, the prevalence of C. psittaci was significantly higher in MALT lymphomas (22%) than in non-LPD (10%, p=0.042) and non-marginal zone lymphoma cases (9%, p=0.033). However, the prevalence of C. psittaci infection in MALT lymphoma showed marked variation among the six geographical regions examined, being most frequent in Germany (47%), followed by the East Coast of the USA (35%) and the Netherlands (29%), but relatively low in Italy (13%), the UK (12%), and Southern China (11%). No significant differences in the detection of C. pneumoniae, C. trachomatis, HSV1, HSV2, ADV8, and ADV19 were found between lymphomas and controls from different geographical regions. In conclusion, our results show that C. psittaci, but not C. pneumoniae, C. trachomatis, HSV1, HSV2, ADV8 or ADV19, is associated with ocular adnexal MALT lymphoma and that this association is variable in different geographical areas.


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