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    Predicting compliance in a breast cancer prevention trial.

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    Authors
    Maurice, Andrew
    Howell, Anthony
    Evans, D Gareth R
    O'Neill, Alison C
    Scobie, Sue
    Affiliation
    Breast Cancer Family History Clinic, Nightingale Center, Withington Hospital, South Manchester University Hospital Trust, Manchester, UK. andrew.maurice@smuht.nwest.nhs.uk
    Issue Date
    2006
    
    Metadata
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    Abstract
    The impact of chemoprevention trials can be hampered by poor participant compliance with the study medication. We used medication monitoring systems and pill count data to try to establish factors that may predict compliance with the International Breast Intervention Study (IBIS) and whether the participants went on to complete or benefit the trial. Women who took their trial medication in a regular pattern rather than randomly were more likely to be of benefit to the study (p = 0.003). For those women who failed to complete the study, compliance was shown to gradually reduce at each follow-up appointment. The taking of additional prescribed medication and not smoking were important factors in predicting completion (p = 0.04 and p = 0.047, respectively) and benefit (p = 0.037 and p = 0.031, respectively) to the study. Taking these factors into account when advising women at the start of a chemoprevention trial may be helpful in improving compliance.
    Citation
    Predicting compliance in a breast cancer prevention trial., 12 (5):446-50 Breast J
    Journal
    The Breast Journal
    URI
    http://hdl.handle.net/10541/72513
    DOI
    10.1111/j.1075-122X.2006.00295.x
    PubMed ID
    16958964
    Type
    Article
    Language
    en
    ISSN
    1075-122X
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1075-122X.2006.00295.x
    Scopus Count
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