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    A comparative study of neovascularisation in atherosclerotic plaques using CD31, CD105 and TGF beta 1.

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    Authors
    Li, Chenggang
    Mollahan, Pamela
    Baguneid, Mohamed S
    McMahon, R
    Kumar, Patricia
    Walker, Michael G
    Freemont, Anthony J
    Kumar, Shant
    Affiliation
    Department of Pathology, Medical School and Christie Hospital, University of Manchester, Manchester, UK.
    Issue Date
    2006
    
    Metadata
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    Abstract
    OBJECTIVES: This study aims to identify plaque neovascularisation using antibodies to CD31, CD105 and TGFbeta1, and to compare their patterns of expression. METHODS: Tissue expression of CD31, CD105 and TGFbeta1 was examined immunohistologically in atherosclerotic plaques from 53 patients who had undergone carotid endarterectomy and in 10 controls. RESULTS: CD31 was observed in a proportion of the microvessels within atheroma. The expression of CD105 was barely visible in normal arteries, but was markedly enhanced in atherosclerotic plaques. The vast majority of the microvessels in atheroma were positive for CD105 with pronounced expression around the periphery of the lipid core. In consecutive sections, microvessels showing negative staining for CD31 were positive for CD105. Although TGFbeta1 was seen in the thickened intima, it was more strongly expressed in well-formed fibrous plaques. Consecutive sections showed that some microvessels were stained by both CD105 and TGFbeta1, but in certain areas microvessels were exclusively CD105 positive. CONCLUSIONS: These observations highlight the distinctive expression patterns of CD31, CD105 and TGFbeta1, suggesting their specific roles in the development of atherosclerotic plaques. CD105 is almost universally expressed in microvessels within the atheroma and is therefore a better vascular marker than CD31 and TGFbeta1for assessing neovascularisation in atherosclerotic plaques.
    Citation
    A comparative study of neovascularisation in atherosclerotic plaques using CD31, CD105 and TGF beta 1. 2006, 73 (4):192-7 Pathobiology
    Journal
    Pathobiology
    URI
    http://hdl.handle.net/10541/72433
    DOI
    10.1159/000096020
    PubMed ID
    17119348
    Type
    Article
    Language
    en
    ISSN
    1015-2008
    ae974a485f413a2113503eed53cd6c53
    10.1159/000096020
    Scopus Count
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