• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Murray, Robert D
    Adams, Judith E
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, United Kingdom.
    Issue Date
    2006-02
    
    Metadata
    Show full item record
    Abstract
    CONTEXT: Low bone mass is a characteristic feature of the adult GH deficiency (GHD) syndrome, but recent dual-energy x-ray absorptiometry (DXA) studies in patients with GH-receptor and GHRH-receptor gene mutations suggest that the situation is more complex. OBJECTIVE: The objective was to define bone areal and volumetric densities and morphometry in hypopituitary adults. DESIGN: The study was a cross-sectional case-controlled study performed between 1999 and 2001. SETTING: The study was undertaken at an endocrine tertiary referral center. PATIENTS: Thirty patients with GHD, 24 with GH insufficiency (GHI) [peak GH, 3-7 microg/liter (9-21 mU/liter)], and 30 age- and sex-matched controls were included for study. MAIN OUTCOME MEASURES: DXA and peripheral quantitative computed tomography (pQCT) derived bone density and morphometry were measured. RESULTS: No densitometric or morphometric abnormalities were detected in GHD patients who acquired their deficiency during adult life. GHD adults of childhood-onset (CO-GHD) showed decreased bone mineral density at the lumbar spine and hip on DXA. pQCT of the radius showed that CO-GHD patients have normal trabecular bone mineral density and only a 2% decrease in cortical density. Radial bone area was reduced 14.5%, cortical thickness 20%, and cortical cross-sectional area 23%, culminating in a reduction in cortical bone of 25%. The "apparent" low DXA bone density in CO-GHD adults therefore relates primarily to reduced cortical thickness and smaller bone area. DXA and pQCT data derived from adults with GHI revealed no evidence of densitometric or morphometric abnormalities. CONCLUSIONS: 1) Adult-onset GHD patients have normal bone density and size. 2) CO-GHD adults have marginally reduced cortical density but significantly reduced cortical bone as a result of reduced cortical thickness and bone size. 3) GHI has no measurable impact on the skeleton.
    Citation
    A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency. 2006, 91 (2):432-8 J. Clin. Endocrinol. Metab.
    Journal
    The Journal of Clinical Endocrinology and Metabolism
    URI
    http://hdl.handle.net/10541/72420
    DOI
    10.1210/jc.2005-0897
    PubMed ID
    16278268
    Type
    Article
    Language
    en
    ISSN
    0021-972X
    ae974a485f413a2113503eed53cd6c53
    10.1210/jc.2005-0897
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Adults with partial growth hormone deficiency have an adverse body composition.
    • Authors: Murray RD, Adams JE, Shalet SM
    • Issue date: 2004 Apr
    • Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism.
    • Authors: Colao A, Di Somma C, Pivonello R, Loche S, Aimaretti G, Cerbone G, Faggiano A, Corneli G, Ghigo E, Lombardi G
    • Issue date: 1999 Jun
    • Abnormalities in bone mineral density distribution and bone scintigraphy in patients with childhood onset hypopituitarism.
    • Authors: Kosowicz J, El Ali Z, Ziemnicka K, Sowinski J
    • Issue date: 2007 Jul-Sep
    • The impact of idiopathic childhood-onset growth hormone deficiency (GHD) on bone mass in subjects without adult GHD.
    • Authors: Lange M, Müller J, Svendsen OL, Kastrup KW, Juul A, Feldt-Rasmussen U
    • Issue date: 2005 Jan
    • Impact of the growth hormone replacement on bone status in growth hormone deficient adults.
    • Authors: Kužma M, Kužmová Z, Zelinková Z, Killinger Z, Vaňuga P, Lazurová I, Tomková S, Payer J
    • Issue date: 2014 Feb
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.