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    Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies.

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    Authors
    Dodd, R L
    Slevin, Nicholas J
    Affiliation
    Manchester University Medical School, UK.
    Issue Date
    2006-09
    
    Metadata
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    Abstract
    Adenoid cystic carcinoma (ACC) accounts for about 1% of all head and neck malignancies. It has a tendency for a prolonged clinical course, with local recurrences and distant metastases sometimes occurring many years after presentation. Standard treatment for salivary gland ACC is surgery and post-operative radiotherapy. The aim of this review was to examine the reported efficacy of various chemotherapy regimens and molecular therapies on recurrent/metastatic salivary gland ACC. One hundred and fourteen publications were reviewed on chemotherapy as well as possible molecular targets of therapy, including KIT, epidermal growth factor receptor (EGFR), human epidermal growth receptor-2 (HER-2), oestrogen and progesterone receptors, proliferating cell nuclear antigen (PCNA), Ki-67 and the p53, bcl-2 and SOX-4 genes. Reported response rates to combination chemotherapy are low and response duration generally short lived. The response to molecular therapies is low also. More research into novel molecular targets is needed.
    Citation
    Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies. 2006, 42 (8):759-69 Oral Oncol.
    Journal
    Oral Oncology
    URI
    http://hdl.handle.net/10541/72335
    DOI
    10.1016/j.oraloncology.2006.01.001
    PubMed ID
    16757203
    Type
    Article
    Language
    en
    ISSN
    1368-8375
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.oraloncology.2006.01.001
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