AffiliationDepartment of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. email@example.com
MetadataShow full item record
AbstractAccumulating epidemiological evidence shows that being either overweight or obese, in other words having excess body weight (EBW), is associated with an increased risk of several, common, adult cancers. The molecular mechanisms that underlie these associations are not understood fully, but insulin resistance is likely to be important. The insulin-cancer hypothesis postulates that chronic hyperinsulinemia is associated with decreased concentrations of insulin-like growth factor binding protein1 (IGFBP-1) and IGFBP-2, leading to increased availability of IGF-I and concomitant changes in the cellular environment that favor tumor formation. However, the situation is likely to be more complex because hyperinsulinemia is also associated with alterations in related molecular systems (e.g. sex steroids and adipocytokines). As the prevalence of EBW increases to epidemic proportions, untangling the links between EBW and the insulin-IGF axis and its wider molecular interactions will become increasingly important in the development of preventive strategies.
CitationObesity and cancer risk: the role of the insulin-IGF axis. 2006, 17 (8):328-36 Trends Endocrinol. Metab.
JournalTrends in Endocrinology and Metabolism
- Energy balance, physical activity, and cancer risk.
- Authors: Fair AM, Montgomery K
- Issue date: 2009
- Obesity and cancer: pathophysiological and biological mechanisms.
- Authors: Renehan AG, Roberts DL, Dive C
- Issue date: 2008 Feb
- Interactions between insulin, body fat, and insulin-like growth factor axis proteins.
- Authors: Ahmed RL, Thomas W, Schmitz KH
- Issue date: 2007 Mar
- The insulin-like growth factors and insulin-signalling systems: an appealing target for breast cancer therapy?
- Authors: Gray SG, Stenfeldt Mathiasen I, De Meyts P
- Issue date: 2003 Nov-Dec
- Insulin and cancer.
- Authors: Boyd DB
- Issue date: 2003 Dec