Normal levels of serum IGF-I: determinants and validity of current reference ranges.
| dc.contributor.author | Brabant, Georg E | |
| dc.contributor.author | Wallaschofski, Henri | |
| dc.date.accessioned | 2009-06-30T14:33:32Z | |
| dc.date.available | 2009-06-30T14:33:32Z | |
| dc.date.issued | 2007 | |
| dc.identifier.citation | Normal levels of serum IGF-I: determinants and validity of current reference ranges. 2007, 10 (2):129-33 Pituitary | en |
| dc.identifier.issn | 1386-341X | |
| dc.identifier.pmid | 17487588 | |
| dc.identifier.doi | 10.1007/s11102-007-0035-9 | |
| dc.identifier.uri | http://hdl.handle.net/10541/71982 | |
| dc.description.abstract | Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over- or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I. | |
| dc.language.iso | en | en |
| dc.subject.mesh | Disease Susceptibility | |
| dc.subject.mesh | Female | |
| dc.subject.mesh | Human Growth Hormone | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Insulin-Like Growth Factor I | |
| dc.subject.mesh | Male | |
| dc.subject.mesh | Reference Values | |
| dc.subject.mesh | Reproducibility of Results | |
| dc.title | Normal levels of serum IGF-I: determinants and validity of current reference ranges. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Endocrinology, Christie Hospital, Wilmslow Rd, Manchester M20 4BX, UK. georg.Brabant@Manchester.ac.uk | en |
| dc.identifier.journal | Pituitary | en |
| html.description.abstract | Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over- or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I. |