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dc.contributor.authorRoman, Eve
dc.contributor.authorSimpson, Jill
dc.contributor.authorAnsell, Pat
dc.contributor.authorKinsey, Sally E
dc.contributor.authorMitchell, Christopher D
dc.contributor.authorMcKinney, Patricia A
dc.contributor.authorBirch, Jillian M
dc.contributor.authorGreaves, Martin J
dc.contributor.authorEden, Tim O B
dc.date.accessioned2009-06-30T14:30:39Z
dc.date.available2009-06-30T14:30:39Z
dc.date.issued2007-03-01
dc.identifier.citationChildhood acute lymphoblastic leukemia and infections in the first year of life: a report from the United Kingdom Childhood Cancer Study. 2007, 165 (5):496-504 Am. J. Epidemiol.en
dc.identifier.issn0002-9262
dc.identifier.pmid17182983
dc.identifier.doi10.1093/aje/kwk039
dc.identifier.urihttp://hdl.handle.net/10541/71981
dc.description.abstractThe United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure to infectious diseases. The authors analyzed the relation between diagnosis (1991-1996) of acute lymphoblastic leukemia (ALL) at ages 2-5 years and clinically diagnosed infections in infancy. Almost all study children (96% of both cases and controls) were taken to a general practitioner for a non-immunization-associated visit at least once before their first birthday. Children diagnosed with ALL had significantly more clinically diagnosed infectious episodes in infancy than did controls; the average number of episodes was 3.6 (95% confidence interval (CI): 3.3, 3.9) versus 3.1 (95% CI: 2.9, 3.2). This case-control difference was most apparent in the neonatal period (< or =1 month); 18% of controls and 24% of ALL cases were diagnosed with at least one infection (odds ratio = 1.4, 95% CI: 1.1, 1.9; p < 0.05). Cases who had more than one neonatal infectious episode tended to be diagnosed with ALL at a comparatively young age; the mean age at ALL diagnosis was 37.7 months for cases with two or more episodes versus 45.3 months for cases with only one episode or none (p < 0.01). These findings support the hypothesis that a dysregulated immune response to infection in the first few months of life promotes transition to overt ALL later in childhood.
dc.language.isoenen
dc.subject.meshAge of Onset
dc.subject.meshCase-Control Studies
dc.subject.meshChild, Preschool
dc.subject.meshConfidence Intervals
dc.subject.meshFemale
dc.subject.meshGreat Britain
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshInfection
dc.subject.meshMale
dc.subject.meshOdds Ratio
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshRisk Factors
dc.titleChildhood acute lymphoblastic leukemia and infections in the first year of life: a report from the United Kingdom Childhood Cancer Study.en
dc.typeArticleen
dc.contributor.departmentEpidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom. eve.roman@egu.york.ac.uken
dc.identifier.journalAmerican Journal of Epidemiologyen
html.description.abstractThe United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure to infectious diseases. The authors analyzed the relation between diagnosis (1991-1996) of acute lymphoblastic leukemia (ALL) at ages 2-5 years and clinically diagnosed infections in infancy. Almost all study children (96% of both cases and controls) were taken to a general practitioner for a non-immunization-associated visit at least once before their first birthday. Children diagnosed with ALL had significantly more clinically diagnosed infectious episodes in infancy than did controls; the average number of episodes was 3.6 (95% confidence interval (CI): 3.3, 3.9) versus 3.1 (95% CI: 2.9, 3.2). This case-control difference was most apparent in the neonatal period (< or =1 month); 18% of controls and 24% of ALL cases were diagnosed with at least one infection (odds ratio = 1.4, 95% CI: 1.1, 1.9; p < 0.05). Cases who had more than one neonatal infectious episode tended to be diagnosed with ALL at a comparatively young age; the mean age at ALL diagnosis was 37.7 months for cases with two or more episodes versus 45.3 months for cases with only one episode or none (p < 0.01). These findings support the hypothesis that a dysregulated immune response to infection in the first few months of life promotes transition to overt ALL later in childhood.


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