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    Childhood acute lymphoblastic leukemia and infections in the first year of life: a report from the United Kingdom Childhood Cancer Study.

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    Authors
    Roman, Eve
    Simpson, Jill
    Ansell, Pat
    Kinsey, Sally E
    Mitchell, Christopher D
    McKinney, Patricia A
    Birch, Jillian M
    Greaves, Martin J
    Eden, Tim O B
    Affiliation
    Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom. eve.roman@egu.york.ac.uk
    Issue Date
    2007-03-01
    
    Metadata
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    Abstract
    The United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure to infectious diseases. The authors analyzed the relation between diagnosis (1991-1996) of acute lymphoblastic leukemia (ALL) at ages 2-5 years and clinically diagnosed infections in infancy. Almost all study children (96% of both cases and controls) were taken to a general practitioner for a non-immunization-associated visit at least once before their first birthday. Children diagnosed with ALL had significantly more clinically diagnosed infectious episodes in infancy than did controls; the average number of episodes was 3.6 (95% confidence interval (CI): 3.3, 3.9) versus 3.1 (95% CI: 2.9, 3.2). This case-control difference was most apparent in the neonatal period (< or =1 month); 18% of controls and 24% of ALL cases were diagnosed with at least one infection (odds ratio = 1.4, 95% CI: 1.1, 1.9; p < 0.05). Cases who had more than one neonatal infectious episode tended to be diagnosed with ALL at a comparatively young age; the mean age at ALL diagnosis was 37.7 months for cases with two or more episodes versus 45.3 months for cases with only one episode or none (p < 0.01). These findings support the hypothesis that a dysregulated immune response to infection in the first few months of life promotes transition to overt ALL later in childhood.
    Citation
    Childhood acute lymphoblastic leukemia and infections in the first year of life: a report from the United Kingdom Childhood Cancer Study. 2007, 165 (5):496-504 Am. J. Epidemiol.
    Journal
    American Journal of Epidemiology
    URI
    http://hdl.handle.net/10541/71981
    DOI
    10.1093/aje/kwk039
    PubMed ID
    17182983
    Type
    Article
    Language
    en
    ISSN
    0002-9262
    ae974a485f413a2113503eed53cd6c53
    10.1093/aje/kwk039
    Scopus Count
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    All Christie Publications

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