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dc.contributor.authorKulkarni, Bhavna
dc.contributor.authorBentley, D E
dc.contributor.authorElliott, R
dc.contributor.authorJulyan, Peter J
dc.contributor.authorBoger, E
dc.contributor.authorWatson, A
dc.contributor.authorBoyle, Y
dc.contributor.authorEl-Deredy, W
dc.contributor.authorJones, Anthony K P
dc.date.accessioned2009-06-30T14:16:36Z
dc.date.available2009-06-30T14:16:36Z
dc.date.issued2007-04
dc.identifier.citationArthritic pain is processed in brain areas concerned with emotions and fear. 2007, 56 (4):1345-54 Arthritis Rheum.en
dc.identifier.issn0004-3591
dc.identifier.pmid17393440
dc.identifier.doi10.1002/art.22460
dc.identifier.urihttp://hdl.handle.net/10541/71960
dc.description.abstractOBJECTIVE: Functional neuroimaging studies have shown that experimentally induced acute pain is processed within at least 2 parallel networks of brain structures collectively known as the pain matrix. The relevance of this finding to clinical pain is not known, because no direct comparisons of experimental and clinical pain have been performed in the same group of patients. The aim of this study was to compare directly the brain areas involved in processing arthritic pain and experimental pain in a group of patients with osteoarthritis (OA). METHODS: Twelve patients with knee OA underwent positron emission tomography of the brain, using (18)F-fluorodeoxyglucose (FDG). Scanning was performed during 3 different pain states: arthritic knee pain, experimental knee pain, and pain-free. Significant differences in the neuronal uptake of FDG between different pain states were investigated using statistical parametric mapping software. RESULTS: Both pain conditions activated the pain matrix, but arthritic pain was associated with increased activity in the cingulate cortex, the thalamus, and the amygdala; these areas are involved in the processing of fear, emotions, and in aversive conditioning. CONCLUSION: Our results suggest that studies of experimental pain provide a relevant but quantitatively incomplete picture of brain activity during arthritic pain. The search for new analgesics for arthritis that act on the brain should focus on drugs that modify this circuitry.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshBrain
dc.subject.meshBrain Mapping
dc.subject.meshEmotions
dc.subject.meshFear
dc.subject.meshFemale
dc.subject.meshHot Temperature
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOsteoarthritis, Knee
dc.subject.meshPain
dc.subject.meshPain Measurement
dc.subject.meshPhysical Stimulation
dc.subject.meshPositron-Emission Tomography
dc.titleArthritic pain is processed in brain areas concerned with emotions and fear.en
dc.typeArticleen
dc.contributor.departmentHuman Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK. bhavna.kulkarni@manchester.ac.uken
dc.identifier.journalArthritis and Rheumatismen
html.description.abstractOBJECTIVE: Functional neuroimaging studies have shown that experimentally induced acute pain is processed within at least 2 parallel networks of brain structures collectively known as the pain matrix. The relevance of this finding to clinical pain is not known, because no direct comparisons of experimental and clinical pain have been performed in the same group of patients. The aim of this study was to compare directly the brain areas involved in processing arthritic pain and experimental pain in a group of patients with osteoarthritis (OA). METHODS: Twelve patients with knee OA underwent positron emission tomography of the brain, using (18)F-fluorodeoxyglucose (FDG). Scanning was performed during 3 different pain states: arthritic knee pain, experimental knee pain, and pain-free. Significant differences in the neuronal uptake of FDG between different pain states were investigated using statistical parametric mapping software. RESULTS: Both pain conditions activated the pain matrix, but arthritic pain was associated with increased activity in the cingulate cortex, the thalamus, and the amygdala; these areas are involved in the processing of fear, emotions, and in aversive conditioning. CONCLUSION: Our results suggest that studies of experimental pain provide a relevant but quantitatively incomplete picture of brain activity during arthritic pain. The search for new analgesics for arthritis that act on the brain should focus on drugs that modify this circuitry.


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