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    Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis.

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    Authors
    Ockenga, J
    Tietge, U J F
    Böker, K H W
    Manns, M P
    Brabant, Georg E
    Bahr, M J
    Affiliation
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany. johann.ockenga@charite.de
    Issue Date
    2007-06-01
    
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    Abstract
    BACKGROUND: Alteration of the leptin system appears to play a role in the inflammatory-metabolic response in catabolic diseases such as chronic liver diseases. AIM: To investigate the association between leptin components, inflammatory markers and hepatic energy and substrate metabolism. METHODS: We investigated in vivo hepatic substrate and leptin metabolism in 40 patients employing a combination of arterial and hepatic vein catheterization techniques and hepatic blood flow measurements. In addition to metabolic, inflammatory and neuroendocrine parameters, circulating levels of free leptin, bound leptin and soluble leptin receptor were determined. RESULTS: Compared with controls, bound leptin and soluble leptin receptor levels were significantly elevated in cirrhosis, while free leptin did not increase. In cirrhosis bound leptin was correlated with soluble leptin receptor (r = 0.70, P < 0.001). Free leptin was positively correlated with metabolic parameters such as energy storage (body fat mass; r = 0.36, P < 0.05), insulin and insulin resistance (r = 0.48; r = 0.46, P < 0.01) as well as with hepatic glucose and energy release (r = 0.35 and r = 0.40, P < 0.05). In contrast, bound leptin and soluble leptin receptor were linked to proinflammatory cytokines and sympathetic activity (r = 0.61 and r = 0.56, P < 0.01). CONCLUSION: The components of the leptin system (free leptin, bound leptin and soluble leptin receptor) have distinct roles in metabolic and inflammatory processes in patients with liver cirrhosis. The better understanding of this metabolic and inflammatory tissue-repair response may lead to innovative new therapeutic strategies in liver disease as well as in various other catabolic diseases.
    Citation
    Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis. 2007, 25 (11):1301-9 Aliment. Pharmacol. Ther.
    Journal
    Alimentary Pharmacology & Therapeutics
    URI
    http://hdl.handle.net/10541/71958
    DOI
    10.1111/j.1365-2036.2007.03327.x
    PubMed ID
    17509098
    Type
    Article
    Language
    en
    ISSN
    0269-2813
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2036.2007.03327.x
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