DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents.
AffiliationImaging Science and Biomedical Engineering, University of Manchester, Oxford Road, Manchester M13 9PT, UK.firstname.lastname@example.org
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AbstractDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T(1)-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.
CitationDCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. 2007, 96 (2):189-95 Br. J. Cancer
JournalBritish Journal of Cancer