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    DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents.

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    Authors
    O'Connor, James P B
    Jackson, Alan
    Parker, Geoff J M
    Jayson, Gordon C
    Affiliation
    Imaging Science and Biomedical Engineering, University of Manchester, Oxford Road, Manchester M13 9PT, UK.james.o'connor@manchester.ac.uk
    Issue Date
    2007-01-29
    
    Metadata
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    Abstract
    Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T(1)-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.
    Citation
    DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. 2007, 96 (2):189-95 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/71933
    DOI
    10.1038/sj.bjc.6603515
    PubMed ID
    17211479
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6603515
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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