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dc.contributor.authorLavelle, K
dc.contributor.authorTodd, Chris
dc.contributor.authorMoran, Anthony
dc.contributor.authorHowell, Anthony
dc.contributor.authorBundred, Nigel J
dc.contributor.authorCampbell, Malcolm
dc.date.accessioned2009-06-30T12:26:09Z
dc.date.available2009-06-30T12:26:09Z
dc.date.issued2007-04-23
dc.identifier.citationNon-standard management of breast cancer increases with age in the UK: a population based cohort of women > or =65 years. 2007, 96 (8):1197-203 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid17387342
dc.identifier.doi10.1038/sj.bjc.6603709
dc.identifier.urihttp://hdl.handle.net/10541/71930
dc.description.abstractEvidence suggests that compared to younger women, older women are less likely to receive standard management for breast cancer. Whether this disparity persists once differences in tumour characteristics have been adjusted for has not been investigated in the UK. A retrospective cohort study involving case note review was undertaken, based on the North Western Cancer Registry database of women aged > or =65 years, resident in Greater Manchester with invasive breast cancer registered over a 1-year period (n=480). Adjusting for tumour characteristics associated with age by logistic regression analyses, older women were less likely to receive standard management than younger women for all indicators investigated. Compared to women aged 65-69 years, women aged > or =80 years with operable (stage 1-3a) breast cancer have increased odds of not receiving triple assessment (OR=5.5, 95% confidence interval (CI): 2.1-14.5), not receiving primary surgery (OR=43.0, 95% CI: 9.7-191.3), not undergoing axillary node surgery (OR=27.6, 95% CI: 5.6-135.9) and not undergoing tests for steroid receptors (OR=3.0, 95% CI: 1.7-5.5). Women aged 75-79 years have increased odds of not receiving radiotherapy following breast-conserving surgery compared to women aged 65-69 years (OR=11.0, 95% CI: 2.0-61.6). These results demonstrate that older women in the UK are less likely to receive standard management for breast cancer, compared to younger women and this disparity cannot be explained by differences in tumour characteristics.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBreast Neoplasms
dc.subject.meshCohort Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMultivariate Analysis
dc.subject.meshReceptors, Estrogen
dc.subject.meshReceptors, Progesterone
dc.titleNon-standard management of breast cancer increases with age in the UK: a population based cohort of women > or =65 years.en
dc.typeArticleen
dc.contributor.departmentSchool of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK. katrina.j.lavelle@manchester.ac.uken
dc.identifier.journalBritish Journal of Canceren
html.description.abstractEvidence suggests that compared to younger women, older women are less likely to receive standard management for breast cancer. Whether this disparity persists once differences in tumour characteristics have been adjusted for has not been investigated in the UK. A retrospective cohort study involving case note review was undertaken, based on the North Western Cancer Registry database of women aged > or =65 years, resident in Greater Manchester with invasive breast cancer registered over a 1-year period (n=480). Adjusting for tumour characteristics associated with age by logistic regression analyses, older women were less likely to receive standard management than younger women for all indicators investigated. Compared to women aged 65-69 years, women aged > or =80 years with operable (stage 1-3a) breast cancer have increased odds of not receiving triple assessment (OR=5.5, 95% confidence interval (CI): 2.1-14.5), not receiving primary surgery (OR=43.0, 95% CI: 9.7-191.3), not undergoing axillary node surgery (OR=27.6, 95% CI: 5.6-135.9) and not undergoing tests for steroid receptors (OR=3.0, 95% CI: 1.7-5.5). Women aged 75-79 years have increased odds of not receiving radiotherapy following breast-conserving surgery compared to women aged 65-69 years (OR=11.0, 95% CI: 2.0-61.6). These results demonstrate that older women in the UK are less likely to receive standard management for breast cancer, compared to younger women and this disparity cannot be explained by differences in tumour characteristics.


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