Show simple item record

dc.contributor.authorHornillo-Araujo, Ana R
dc.contributor.authorBurrell, Adam J M
dc.contributor.authorAiertza, Miren K
dc.contributor.authorShibata, Takayuki
dc.contributor.authorHammond, David M
dc.contributor.authorEdmont, Dolores
dc.contributor.authorAdams, Harry
dc.contributor.authorMargison, Geoffrey P
dc.contributor.authorWilliams, David M
dc.date.accessioned2009-06-23T15:44:49Z
dc.date.available2009-06-23T15:44:49Z
dc.date.issued2007
dc.identifier.citationThe synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. 2007, 26 (8-9):1099-102 Nucleosides Nucleotides Nucleic Acidsen
dc.identifier.issn1525-7770
dc.identifier.pmid18058544
dc.identifier.doi10.1080/15257770701519221
dc.identifier.urihttp://hdl.handle.net/10541/71361
dc.description.abstractThe syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.
dc.language.isoenen
dc.subject.meshCrystallography, X-Ray
dc.subject.meshDrug Design
dc.subject.meshEnzyme Inhibitors
dc.subject.meshGuanine
dc.subject.meshHumans
dc.subject.meshKinetics
dc.subject.meshMolecular Structure
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase
dc.titleThe synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.en
dc.typeArticleen
dc.contributor.departmentCentre for Chemical Biology, Department of Chemistry, University of Sheffield, Sheffield, United Kingdom.en
dc.identifier.journalNucleosides, Nucleotides & Nucleic Acidsen
html.description.abstractThe syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.


This item appears in the following Collection(s)

Show simple item record