The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
Authors
Hornillo-Araujo, Ana RBurrell, Adam J M
Aiertza, Miren K
Shibata, Takayuki
Hammond, David M
Edmont, Dolores
Adams, Harry
Margison, Geoffrey P
Williams, David M
Affiliation
Centre for Chemical Biology, Department of Chemistry, University of Sheffield, Sheffield, United Kingdom.Issue Date
2007
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Show full item recordAbstract
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.Citation
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. 2007, 26 (8-9):1099-102 Nucleosides Nucleotides Nucleic AcidsJournal
Nucleosides, Nucleotides & Nucleic AcidsDOI
10.1080/15257770701519221PubMed ID
18058544Type
ArticleLanguage
enISSN
1525-7770ae974a485f413a2113503eed53cd6c53
10.1080/15257770701519221
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